Understanding peroxynitrite biochemistry and its potential for treating human diseases.
Understanding peroxynitrite biochemistry and its potential for treating human diseases.
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DOI：
10.1016/j.abb.2009.03.013
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发表时间：
2009-04-15
影响因子：
3.9
通讯作者：
Beckman JS
中科院分区：
文献类型：
--
作者：
Beckman JS
很高兴看到这些关于过氧亚硝酸盐生物化学的主要贡献被收集在这个系列中，并被允许在这里分享一些有偏见的观察结果。1992年，《生物化学与生物物理学档案》在我科学生涯的关键时刻发挥了重要作用。在一年多的时间里，我们的研究被《科学》、《自然》和《生物化学杂志》拒之门外。相比之下，《档案库》的编辑允许我们发表一系列五篇论文，证明过氧亚硝酸盐是一种生物氧化剂，展示了酪氨酸硝化如何用于定量过氧亚硝酸盐的产生，并证明过氧亚硝酸盐对细菌有很大的毒性。来自Archives的评论是有洞察力的，而不是对结果是否足够有趣的判断。拉斐尔·拉迪（Rafael Radi）在他的档案论文中也有类似的经历，该论文是关于过氧亚硝酸盐诱导的脂质不依赖铁的氧化。虽然被《X》杂志评为“读者没有足够的兴趣”，但这篇论文现在已经被引用了1200多次。由于有足够的空间来完整地描述实验工作，而不是局限于晦涩的脚注，这些论文比我的团队在知名期刊上发表的其他论文获得了更多的引用。像《档案》这样的期刊在允许发表新的假设和数据方面发挥着重要作用，而这些假设和数据的重要性并没有立即被关注高影响力的期刊所认识到。像Pubmed这样的网络访问在世界范围内提供了同等的曝光率。对于新研究者来说，你在职业生涯中发表论文的地方可能没有你担心的那么大，从长远来看，在多篇论文中更全面地解释你的研究将带来更大的好处。
It is a great pleasure to see these major contributions on peroxynitrite biochemistry to be collected in this series and to be permitted to share a few biased observations here. The Archives of Biochemistry and Biophysics played a major role at a critical junction in my scientific career in 1992. For over a year, our work had been rejected after lengthy review times by Science, Nature and the Journal of Biological Chemistry. In contrast, the editors of Archives allowed us to publish a series of five papers that established peroxynitrite as a biological oxidant, showed how tyrosine nitration can be used to quantify peroxynitrite production and demonstrated that peroxynitrite was quite toxic to bacteria. The reviews from Archives were insightful rather than being judgmental as to whether the results were of sufficient interest. Rafael Radi has a similar experience with his Archives paper on the iron-independent oxidation of lipids induced by peroxynitrite. While judged “not of sufficient interest for the readers“ of journal X, the paper has now been cited over 1200 times. By having the space to fully describe the experimental work rather than being confined to cryptic footnotes, these papers has have received many more citations than other papers that my group has published in high profile journals. Journals such as Archives play an important role in allowing new hypotheses and data to be published of which the importance is not immediately recognized by journals focused on high impact. Access over the web such as by Pubmed gives equal exposure around the world. For new investigators, the difference in where you publish on your career may not be as great as you fear and the benefits of more fully explaining your research in multiple papers in the long run will carry greater weight.
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DOI：
10.1159/000170883
发表时间：
2009
期刊：
Neuro-degenerative diseases
影响因子：
--
作者：
Irizarry MC;Raman R;Schwarzschild MA;Becerra LM;Thomas RG;Peterson RC;Ascherio A;Aisen PS
通讯作者：
Aisen PS
影响因子：
4.1
作者：
Hinson, JA;Pike, SL;Mayeux, PR
通讯作者：
Mayeux, PR
影响因子：
3.9
作者：
ISCHIROPOULOS, H;ZHU, L;BECKMAN, JS
通讯作者：
BECKMAN, JS
影响因子：
7.4
作者：
CROW, JP;SPRUELL, C;BECKMAN, JS
通讯作者：
BECKMAN, JS
影响因子：
4.8
作者：
Reiter, CD;Teng, RJ;Beckman, JS
通讯作者：
Beckman, JS