Prior morphine exposure enhances ibogaine antagonism of morphine-induced dopamine release in rats.
Prior morphine exposure enhances ibogaine antagonism of morphine-induced dopamine release in rats.
复制标题
先前的吗啡暴露增强了伊博加因对吗啡诱导的大鼠多巴胺释放的拮抗作用。
DOI：
10.1016/s0028-3908(96)00116-5
复制
发表时间：
1996
影响因子：
4.7
通讯作者：
Glick,SD
中科院分区：
文献类型：
--
作者：
Pearl,SM;Maisonneuve,IM;Glick,SD
本研究探讨了先前吗啡暴露对伊波替尼拮抗吗啡诱导的多巴胺释放的影响。将雌性Sprague-Dawley大鼠每天一次用吗啡（20 mg/kg，i. p.）或生理盐水，并给予低剂量的伊波替尼（10 mg/kg，i. p.）或生理盐水。19小时后，用吗啡（5 mg/kg，i. p.）攻击大鼠（清醒和自由活动），用活体微透析法监测纹状体和中脑核中的多巴胺及其代谢产物。无论是生理盐水预处理，吗啡预处理，也没有iboclavin单独改变吗啡诱导的细胞外多巴胺和多巴胺代谢产物的增加在任一结构。然而，当吗啡预处理与伊波替尼结合时，吗啡诱导的多巴胺升高，但不是代谢产物，被完全阻断。这些数据表明，先前的吗啡暴露增强了伊波替尼对多巴胺能系统的阿片拮抗剂作用，并且先前的药物暴露可能是伊波替尼治疗阿片类成瘾的疗效和/或效力的临床显著决定因素。©爱思唯尔科学有限公司版权所有。
The present study examines the effect of prior morphine exposure on ibogaine antagonism of morphine-induced dopamine release. Female Sprague-Dawley rats were pretreated once a day for 2 days with morphine (20 mg/kg, i.p.) or saline and given a low dose of ibogaine (10 mg/kg, i.p.) or saline 5 hr after the last morphine or saline injection. Nineteen hours later, rats (awake and freely moving) were challenged with morphine (5 mg/kg, i.p.), and dopamine and its metabolites were monitored in the striatum and nucleus accumbens using in vivo microdialysis. Neither saline pretreatment, morphine pretreatment, nor ibogaine alone altered morphine-induced increases in extracellular dopamine and dopamine metabolites in either structure. However, when morphine pretreatment was combined with ibogaine, the morphine-induced elevation of dopamine, but not of metabolites, was completely blocked. These data suggest that prior morphine exposure enhances an opioid antagonist action of ibogaine on dopaminergic systems and that prior drug exposure may be a clinically significant determinant of ibogaine efficacy and/or potency in the treatment of opioid addiction. © Elsevier Science Ltd. All rights reserved.