VIRULENCE FOR MICE OF KLEBSIELLA STRAINS BELONGING TO THE 01-GROUP - RELATIONSHIP TO THEIR CAPSULAR (K) TYPES
VIRULENCE FOR MICE OF KLEBSIELLA STRAINS BELONGING TO THE 01-GROUP - RELATIONSHIP TO THEIR CAPSULAR (K) TYPES
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DOI：
10.1128/iai.40.1.56-61.1983
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发表时间：
1983-01-01
影响因子：
3.1
通讯作者：
KATO, N
中科院分区：
文献类型：
--
作者：
MIZUTA, K;OHTA, M;KATO, N
通过腹腔接种，检测了属于不同K型的克雷伯菌O1菌株（82株）对小鼠的毒力。其中包括49株新分离的临床菌株、31株参考菌株和2株实验室菌株。9株O1：K2型克雷伯氏菌中，有7株为强毒力，LD_（50）< 10个菌落形成单位，其余2株为无毒力。克雷伯氏菌K2参考株B5055和Chedid株在体外长期保存，毒力强。8株O1：K1型克雷伯菌中，2株为中等毒力，6株为弱毒力或无毒力。未发现克雷伯菌K1和K2菌株对小鼠的毒力性质与其来源的临床标本之间存在明确的相关性。除K1和K2外，所有测试的属于K型的克雷伯氏菌O1菌株对小鼠表现出非常低的毒力或没有毒力。
Klebsiella O1 strains (82) belonging to various K types were tested for virulence for mice by i.p. inoculation. They comprised 49 strains newly isolated from various clinical specimens, 31 reference strains and 2 laboratory strains. Of 9 Klebsiella O1:K2 strains, 7 were highly virulent; their LD50 per mouse were < 10 colony forming units; the other 2 strains were avirulent even when encapsulated, as revealed by the quellung test. Klebsiella K2 reference strain B5055 and strain Chedid, which were maintained in vitro for a long time, were highly virulent. Of 8 Klebsiella O1:K1 strains, 2 showed moderate virulence; the other 6 strains had relatively low or no virulence. No definite correlation was found between the nature of the virulence of Klebsiella K1 and K2 strains for mice and the clinical specimens from which they originated. All of the Klebsiella O1 strains tested belonging to K types other than K1 and K2 showed very low or no virulence for mice.