Effects of the Microparticle Shape on Cellular Uptake.
Effects of the Microparticle Shape on Cellular Uptake.
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DOI：
10.1021/acs.molpharmaceut.5b00992
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发表时间：
2016-07-05
影响因子：
4.9
通讯作者：
Park K
中科院分区：
文献类型：
--
作者：
He Y;Park K
已知微粒和纳米颗粒的物理形式，例如大小、电荷和形状，会影响内吞作用。改善药物载体的物理设计可以提高药物摄取效率和随后的药物功效。简单的形状，如球形和圆柱形，已经研究了它们的内吞能力。为了更好地理解形状对细胞摄取的影响，使用键盘字符形状制备不同的颗粒形状，并检查它们对细胞摄取的影响。结果表明，具有更高纵横比和更尖锐角度特征的形状具有更高的粘附细胞并被癌细胞内化的机会。细胞膜和与细胞膜接触的微粒部分之间的局部相互作用在决定结果中也起着至关重要的作用。
Physical forms of microparticles and nanoparticles, such as the size, charge, and shape, are known to affect endocytosis. Improving the physical designs of the drug carriers can increase the drug uptake efficiency and the subsequent drug efficacy. Simple shapes, such as sphere and cylinder, have been studied for their ability for endocytosis. To have a better understanding of the shape effect on cellular uptake, different particle shapes were prepared, using the keyboard character shapes, and their impacts on cellular uptake were examined. The results showed that shapes with higher aspect ratio and sharper angular features have a higher chance of adhering to the cells and become internalized by the cancer cells. The local interaction between the cell membrane and the part of the microparticle in contact with the cell membrane also plays a crucial role in determining the outcome.