Myocarditis and pericarditis are rare following live viral vaccinations in adults
Myocarditis and pericarditis are rare following live viral vaccinations in adults
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DOI：
10.1016/j.vaccine.2018.02.030
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发表时间：
2018-03-14
期刊：
影响因子：
5.5
通讯作者：
Naleway, Allison L.
中科院分区：
文献类型：
--
作者：
Kuntz, Jennifer;Crane, Bradley;Naleway, Allison L.
成人接种天花疫苗后出现心肌炎和心包炎的报告表明，有必要评估接受活病毒疫苗接种的成人患炎症性心脏病的风险。从1996年到2007年，在疫苗安全数据链中接种疫苗的416,629名成年人中，我们发现了一例可能的心包炎病例，而在活病毒疫苗接种后的42天内没有心肌炎病例。我们的自我控制风险区间分析发现，基于在风险区间内发现的1例和在控制区间内发现的10例，接种后42天内心包炎的风险没有增加（IRR, 0.57; 95% CI, 0.07, 4.51）。我们的研究表明，接种活病毒疫苗后心包炎的发生率很少见，估计发病率为0.24 / 10万，不高于背景率，远低于接种天花疫苗后的发病率。(C) 2018 Elsevier Ltd.版权所有。
Reports of myocarditis and pericarditis following smallpox vaccination in adults suggested a need to assess inflammatory cardiac disease risk among adults who receive live viral vaccinations. From 1996 through 2007, among 416,629 vaccinated adults in the Vaccine Safety Datalink, we identified one probable pericarditis case and no cases of myocarditis in the 42 days following a live viral vaccination. Our self-controlled risk interval analysis found that, based on one case identified during the risk interval and 10 cases during the control interval, there is no increased risk of myopericarditis in the 42 days following vaccination (IRR, 0.57; 95% CI, 0.07, 4.51). Our study suggests that the occurrence of myopericarditis following live viral vaccination is rare with an estimated incidence of 0.24 per 100,000 vaccinated, which is not higher than the background rate and is much lower than the incidence rates reported following smallpox vaccination. (C) 2018 Elsevier Ltd. All rights reserved.