Acute-phase gene expression correlates with intrahepatic tumor necrosis factor-alpha abundance but not with plasma tumor necrosis factor concentrations during sepsis/systemic inflammatory response syndrome in the rat.
Acute-phase gene expression correlates with intrahepatic tumor necrosis factor-alpha abundance but not with plasma tumor necrosis factor concentrations during sepsis/systemic inflammatory response syndrome in the rat.
复制标题
大鼠脓毒症/全身炎症反应综合征期间，急性期基因表达与肝内肿瘤坏死因子-α丰度相关，但与血浆肿瘤坏死因子浓度无关。
DOI：
10.1097/00003246-199612000-00004
复制
发表时间：
1996
影响因子：
8.8
通讯作者：
Deutschman,CS
中科院分区：
文献类型：
--
作者：
Andrejko,KM;Deutschman,CS
目的：为了验证大鼠盲肠结扎和穿孔后，肝脏中肿瘤坏死因子（TNF）/白细胞介素-1依赖的急性期反应物α 1-酸性糖蛋白表达增加的假设，并且这种变化与肝实质中TNF-α丰度的增加暂时相关，但与TNF-α的循环浓度无关。设计
ObjectivesTo test the hypothesis that after cecal ligation and puncture in the rat, there is increased expression of the tumor necrosis factor (TNF)/interleukin-1-dependent, acute-phase reactant alpha 1-acid glycoprotein in the liver, and that this change correlates temporally with increased abundance of TNF-alpha in the hepatic parenchyma but not with circulating concentrations of TNF-alpha.Design