A genetic instrumental variables analysis of the effects of prenatal smoking on birth weight: evidence from two samples.
A genetic instrumental variables analysis of the effects of prenatal smoking on birth weight: evidence from two samples.
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产前吸烟对出生体重影响的遗传工具变量分析：来自两个样本的证据。
DOI：
10.1080/19485565.2011.564468
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发表时间：
2011
影响因子：
1.3
通讯作者：
Lie,RolvT
中科院分区：
文献类型：
--
作者：
Wehby,GeorgeL;Fletcher,JasonM;Lehrer,StevenF;Moreno,LinaM;Murray,JeffreyC;Wilcox,Allen;Lie,RolvT
有大量文献表明，产前吸烟对分娩和儿童健康结果的有害影响。然而，目前尚不清楚这些影响是因果关系还是反映了选择吸烟的母亲的其他特征和选择，这些特征和选择也可能影响儿童健康结果或对吸烟的偏见报告。在这篇文章中，我们使用预测吸烟行为的遗传标记作为工具来解决吸烟选择在生育和儿童健康结果产生中的内生性。我们的结果表明，与忽略产前吸烟内生性的估计相比，产前吸烟导致的出生体重下降幅度更大，这与之前使用非遗传工具进行的研究一致。我们使用来自挪威和美国的两个不同样本的数据，使用不同的测量仪器，发现几乎相同的结果。这项研究提供了一种新的应用，可以扩展到研究对健康以及社会和经济结果的几种行为影响。
There is a large literature showing the detrimental effects of prenatal smoking on birth and childhood health outcomes. It is somewhat unclear, though, whether these effects are causal or reflect other characteristics and choices by mothers who choose to smoke that may also affect child health outcomes or biased reporting of smoking. In this paper, we use genetic markers that predict smoking behaviors as instruments to address the endogeneity of smoking choices in the production of birth and childhood health outcomes. Our results indicate that prenatal smoking produces more dramatic declines in birth weight than estimates that ignore the endogeneity of prenatal smoking, which is consistent with previous studies with non-genetic instruments. We use data from two distinct samples from Norway and the United States with different measured instruments and find nearly identical results. The study provides a novel application that can be extended to study several behavioral impacts on health and social and economic outcomes.