Gastrulation-stage alcohol exposure induces similar rates of craniofacial malformations in male and female C57BL/6J mice.
Gastrulation-stage alcohol exposure induces similar rates of craniofacial malformations in male and female C57BL/6J mice.
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DOI：
10.1002/bdr2.2292
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发表时间：
2023-12
影响因子：
2.1
通讯作者：
K. Boschen;Constance J Dragicevich;Eric W. Fish;Austin J Hepperla;Jeremy M Simon;S. Parnell
中科院分区：
文献类型：
--
作者：
K. Boschen;Constance J Dragicevich;Eric W. Fish;Austin J Hepperla;Jeremy M Simon;S. Parnell
在原肠胚期（小鼠胚胎日[E] 7，人类妊娠第3周），产前酒精暴露会损害眼睛、面部和皮质发育，重现胎儿酒精综合征（FAS）的出生缺陷特征。然而，尚不清楚与FAS相关的颅面特征的患病率或严重程度是否受生理性别的影响。
Prenatal alcohol exposure during gastrulation (embryonic day [E] 7 in mice, ~3rd week of human pregnancy) impairs eye, facial, and cortical development, recapitulating birth defects characteristic of Fetal Alcohol Syndrome (FAS). However, it is not known whether the prevalence or severity of craniofacial features associated with FAS is affected by biological sex.