Diagnosis and prognosis evaluation of 1,2-dichloroethane encephalopathy--magnetic resonance imaging combined with diffusion tensor imaging and magnetic resonance spectroscopy study.
Diagnosis and prognosis evaluation of 1,2-dichloroethane encephalopathy--magnetic resonance imaging combined with diffusion tensor imaging and magnetic resonance spectroscopy study.
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DOI：
10.4103/0028-3886.76884
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发表时间：
2011
期刊：
影响因子：
2.7
通讯作者：
F. Zhan;W. Zheng;Lian Liu;L. Kong
中科院分区：
文献类型：
--
作者：
F. Zhan;W. Zheng;Lian Liu;L. Kong
1，2-二氯乙烷(1，2-DCE)脑病的神经影像表现鲜有报道。我们报告了1例1，2-DCE脑病的综合神经影像表现，常规磁共振成像(MRI)结合扩散张量成像(DTI)和1H-磁共振波谱(1H-MRS)。第4天，磁共振弥散加权像(DWI)的信号强度高于T2加权像(T2WI)，平均表观扩散系数(ADC)值低于对照组。20d时，病灶的平均ADC值逐渐增大，而病灶的平均分数各向异性(FA)明显降低。1H-MRS显示20d时N-乙酰天冬氨酸/肌酐(NAA/Cr)和NAA/胆碱(NAA/Cho)的比值均低于对照组。常规MRI、DTI和MRS联合应用对1，2-二氯乙烷所致脑病的早期诊断和预后判断有重要价值。
Neuroimaging findings in 1,2-dichloroethane (1,2-DCE) encephalopathy have seldom been reported. We present the comprehensive neuroimaging findings, conventional magnetic resonance imaging (MRI) combined with diffusion tensor imaging (DTI) and 1 H-magnetic resonance spectroscopy ( 1 H-MRS), in a case of 1,2-DCE encephalopathy. On day-4 the signal intensity of the lesions on diffusion-weighted imaging (DWI) was higher than that with T2-weighted imaging (T2WI); mean apparent diffusion coefficient (ADC) values for lesions were lower than control values. On day-20, the mean ADC value was increased gradually, whereas the mean fractional anisotropy (FA) of the lesions was significantly reduced. 1 H-MRS showed reduced ratios of N-acetyl aspartate to creatinine (NAA/Cr) and NAA to choline (NAA/Cho) on day-20 as compared with the control values. Combining conventional MRI with DTI and MRS is valuable in the early diagnosis and prognosis of 1,2-DCE-induced encephalopathy.