The influence of time, sex and geographic factors on levels of perfluorooctane sulfonate and perfluorooctanoate in human serum over the last 25 years
The influence of time, sex and geographic factors on levels of perfluorooctane sulfonate and perfluorooctanoate in human serum over the last 25 years
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DOI：
10.1539/joh.46.141
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发表时间：
2004-03-01
影响因子：
3
通讯作者：
Koizumi, A
中科院分区：
文献类型：
--
作者：
Harada, K;Saito, N;Koizumi, A
过去25年时间、性别和地理因素对人类血清中全氟辛烷磺酸和全氟辛酸水平的影响：Kouji HARADA等人，京都大学医学研究生院卫生与环境科学系-全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）是各种应用中重要的全氟化学品（PFC）。最近的研究表明，这些化学物质广泛存在于环境、野生动物和人类中。但影响血清中这些物质水平的因素种类尚不清楚，也不清楚暴露于这些物质是否在增加。为了调查时间、地理位置和性别对这些化学品水平的影响，我们测量了日本宫城、秋田和京都县历史上和最近采集的人类血清样本中的PFOS和PFOA浓度。2003年血清中全氟辛烷磺酸和全氟辛酸浓度[几何平均值（几何标准差）]（微克/升）的范围为：全氟辛烷磺酸在宫城为3.5（2.9）微克/升，京都为28.1（1.5）微克/升，全氟辛酸为2.8（1.5）微克/升，12.4（1.4）微克/升。从女性身上采集的历史样本表明，在过去25年中，全氟辛烷磺酸和全氟辛酸浓度分别增加了3倍和14倍。所有地点血清中全氟辛烷磺酸和全氟辛酸浓度的性别差异都很大。此外，全氟辛烷磺酸和全氟辛酸的浓度存在显著的区域差异。在京都，居住在近畿地区超过2年的居民体内的PFOA浓度明显高于最近迁入该地区的人，无论男女。这一发现表明，在近畿地区有PFOA的来源，提高了其居民的PFOA血清水平。需要进一步的研究来阐明日本近畿地区的这些来源。
The Influence of Time, Sex and Geographic Factors on Levels of Perfluorooctane Sulfonate and Perfluorooctanoate in Human Serum over the Last 25 years: Kouji HARADA, et al. Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine-Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are important perfluorochemicals (PFCs) in various applications. Recently, it has been shown that these chemicals are widespread in the environment, wildlife and humans. But the kinds of factors that affect their levels in serum are unclear, and it is also not clear whether exposure to them is increasing or not. To investigate the impacts of time, geographical location and sex on the levels of these chemicals, we measured PFOS and PFOA concentrations in human sera samples collected both historically and recently in Miyagi, Akita and Kyoto Prefectures in Japan. The PFOS and PFOA levels in sera [Geometric Mean (Geometric Standard Deviation)] (mug/L) in 2003 ranged from 3.5 (2.9) in Miyagi to 28.1 (1.5) in Kyoto for PFOS and from 2.8 (1.5) to 12.4 (1.4) for PFOA. Historical samples collected from females demonstrated that PFOS and PFOA concentrations have increased by factors of 3 and 14, respectively, over the past 25 yr. There are large sex differences in PFOS and PFOA concentrations in serum at all locations. Furthermore, there are predominant regional differences for both PFOS and PFOA concentrations. In Kyoto the concentrations of PFOA in dwellers who had lived in the Kinki area for more than 2 yr were significantly higher than in people who had recently moved into the area, in both sexes. This finding suggests that there are sources of PFOA in the Kinki area that have raised the PFOA serum levels of its inhabitants. Further studies are needed to elucidate these sources in the Kinki area of Japan.