ANATOMIC BASIS OF COGNITIVE-EMOTIONAL INTERACTIONS IN THE PRIMATE PREFRONTAL CORTEX
ANATOMIC BASIS OF COGNITIVE-EMOTIONAL INTERACTIONS IN THE PRIMATE PREFRONTAL CORTEX
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DOI：
10.1016/0149-7634(94)00053-4
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发表时间：
1995-09-01
影响因子：
8.2
通讯作者：
BARBAS, H
中科院分区：
文献类型：
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作者：
BARBAS, H
认识到前额叶皮质的后基底和内侧部分属于边缘系统的皮质组成部分，对于理解其解剖和功能组织非常重要。在灵长类动物中，边缘系统沿着新皮层的进化，并与关联区域保持着紧密的联系。因此，灵长类动物边缘系统结构的损伤导致认知、记忆和情感过程的一系列缺陷。边缘皮层在结构和连接上与真皮层区不同。边缘皮层从深层发出广泛的投射，并通过终止于第I层到达真层区。相比之下，整层区接受的投射来自一组更有限的皮质，当它们与边缘皮质沟通时，它们会从上层发出投射，并以柱状模式终止。边缘皮层的一些连接和神经化学特征在发育过程中的所有区域都被观察到为短暂的特征。解剖学证据表明，边缘系统区域保留了个体发育中观察到的一些特征，这可能解释了它们在学习和记忆中的巨大可塑性和参与，但也解释了它们在几种精神和神经疾病中的优先脆弱性。
Recognition that posterior basal and medial parts of the prefrontal cortex belong to the cortical component of the limbic system was important in understanding their anatomic and functional organization. In primates, the limbic system has evolved along with the neocortex and maintains strong connections with association areas. Consequently, damage to limbic structures in primates results in a series of deficits in cognitive, mnemonic and emotional processes. Limbic cortices differ in their structure and connections from the eulaminate areas. Limbic cortices issue widespread projections from their deep layers and reach eulaminate areas by terminating in layer I. By comparison, the eulaminate areas receive projections from a more restricted set of cortices and when they communicate with limbic cortices they issue projections from their upper layers and terminate in a columnar pattern. Several of the connectional and neurochemical characteristics of limbic cortices are observed as a transient feature in all areas during development. Anatomic evidence suggests that limbic areas retain some features observed in ontogeny, which may explain their great plasticity and involvement in learning and memory, but also their preferential vulnerability in several psychiatric and neurologic disorders.