Hypolipidemic effects of Lysinibacillus sphaericus fermented tomato and carrot juices in high-fat diet-fed albino Wistar rats
Hypolipidemic effects of Lysinibacillus sphaericus fermented tomato and carrot juices in high-fat diet-fed albino Wistar rats
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DOI：
10.7324/jabb.2018.60611
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发表时间：
2018-11
影响因子：
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通讯作者：
N. Seelam;Katike Umamahesh;Peddanna Kotha;H. Akula;Vijaya Sarathi Reddy Obulam
中科院分区：
文献类型：
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作者：
N. Seelam;Katike Umamahesh;Peddanna Kotha;H. Akula;Vijaya Sarathi Reddy Obulam
我们进行了本研究，以评估益生菌番茄汁（PTJ），益生菌胡萝卜汁（PCJ），和他们的混合果汁（PCT）含有球形赖氨酸芽孢杆菌高脂饮食（HFD）喂养的白化病Wistar大鼠的效果。在实验中设计了8组，每组6只大鼠，并将上述益生菌果汁（每只大鼠1-2 mL）口服给HFD喂养的大鼠28天。这包括维持正常对照饮食（NCD）、HFD的组和使用洛伐他汀（以5 mg/kg体重）维持的实验对照组。喂养大鼠后，研究了所有8个组的血清脂质谱。与NCD喂养的大鼠相比，HFD喂养的大鼠显示出升高的脂质水平。益生菌果汁逆转升高的血脂水平接近正常的HFD喂养的大鼠。这种降血脂作用在PCJ喂养（2 mL/大鼠）组中比其他组更显著。与HFD组相比，PTJ治疗时，PCJ和PCT显示体重降低。
We have conducted the present study to evaluate the effect of probioticated tomato juice (PTJ), probioticated carrot juice (PCJ), and their mixed juices (PCT) containing Lysinibacillus sphaericus on high-fat diet (HFD)-fed albino Wistar rats. Eight groups consisting of 6 rats each were designed in the experiments and orally administered the above probioticated juices (at 1–2 mL per rat) to HFD-fed rats for 28 days. This included a group maintained on normal control diet (NCD), HFD, and an experimental control group maintained using lovastatin (at 5 mg/kg body weight). After feeding the rats, the lipid profile of the blood serum was studied in all the eight groups. HFD-fed rats showed elevated lipid profile levels as compared to NCD-fed rats. Probioticated juices reversed the elevated lipid profile levels to near normal in HFD-fed rats. This hypolipidemic effect was more significant in PCJ-fed (2 mL/rat) groups than the other groups. On treatment with the PTJ, PCJ and PCT showed the lowering of body weights when compared to HFD group.