FASTING SERUM-INSULIN CONCENTRATION AND EARLY INSULIN-RESPONSE AS RISK DETERMINANTS FOR DEVELOPING DIABETES
FASTING SERUM-INSULIN CONCENTRATION AND EARLY INSULIN-RESPONSE AS RISK DETERMINANTS FOR DEVELOPING DIABETES
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DOI：
10.1111/j.1464-5491.1990.tb01415.x
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发表时间：
1990-06-01
影响因子：
3.5
通讯作者：
WALDENSTROM, J
中科院分区：
文献类型：
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作者：
LUNDGREN, H;BENGTSSON, C;WALDENSTROM, J
在一项为期12年的前瞻性研究中，348名50岁的女性在随访期间，糖尿病的发病率增加了（17.1%），这些患者最初空腹血糖浓度高于上五分位数，空腹血清胰岛素浓度高于上五分位数（14.9%），静脉葡萄糖耐量试验中血糖消失率低于最低五分位数（12.7%），或早期胰岛素反应低于最低五分位数（17.1%）。所有女性的发病率为4.9%。多因素分析显示，空腹血清胰岛素浓度高的患者风险最高。肥胖和抗高血压药物治疗进一步增加了风险。然而，最初的低早期胰岛素反应并不是发展为明显糖尿病的先决条件。测定空腹胰岛素浓度，特别是超重高血压患者的空腹胰岛素浓度，对于发现哪些患者有患糖尿病的高风险是有价值的。
Among a cohort of 348 women aged 50 on entering a 12‐year prospective study, the incidence of diabetes was increased (17.1%) during follow‐up in those who initially had fasting glucose concentration above the upper quintile, a fasting serum insulin concentration above the upper quintile (14.9%), a disappearance rate of glucose below the lowest quintile in an IV glucose tolerance test (12.7%), or early insulin response below the lowest quintile (17.1%). The incidence in all women was 4.9%. By multivariate analysis, the highest risk was for high fasting serum insulin concentration. Obesity and treatment with antihypertensive drugs further increased the risk. An initial low early insulin response was not however a prerequisite for the development of manifest diabetes. Determination of fasting insulin concentration, especially in overweight hypertensive subjects, is of value in order to find out which subjects are at high risk of developing diabetes.