The influence of smoking, gender, and family history on colorectal adenomas.
The influence of smoking, gender, and family history on colorectal adenomas.
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DOI：
10.1155/2010/509347
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发表时间：
2010
影响因子：
1.8
通讯作者：
Butterly L
中科院分区：
文献类型：
--
作者：
Onega T;Goodrich M;Dietrich A;Butterly L
证据独立地将吸烟、家族史和性别与腺瘤性息肉的风险增加联系起来。利用来自新罕布什尔州结肠镜登记处（2004-2006）的数据，我们在5,395名接受结肠镜筛查的个体中检查了联合危险因素与腺瘤发生的关系。自我报告的吸烟、家族史和其他因素的数据与识别腺瘤性息肉的病理报告相关，并采用多元logistic回归建模。在调整后的模型中，>15包-年吸烟史增加了腺瘤的可能性（OR = 1.54，95% CI 1.28-1.86），尽管≤15包-年没有增加腺瘤的可能性（OR = 1.07，95% CI 0.87-1.32）。性别分层模型显示，即使是男性，在较低的吸烟暴露下，腺瘤的风险也显著增加（OR = 1.32; 95%CI：1.00-1.76），但女性则不然（OR = 0.85; 95%CI：0.61-1.14）。腺瘤发生的有序逻辑回归模型显示，≥15包-年的吸烟史与连续较大尺寸类别的腺瘤几率高61%相关（95% CI 1.34-1.93）。对于有结直肠癌家族史的人来说，吸烟不会进一步增加腺瘤的风险。吸烟时间与腺瘤的发生和大小有关，尤其是男性。
Evidence independently links smoking, family history, and gender with increased risk of adenomatous polyps. Using data from the New Hampshire Colonoscopy Registry (2004–2006), we examined the relation of combined risk factors with adenoma occurrence in 5,395 individuals undergoing screening colonoscopy. Self-reported data on smoking, family history and other factors were linked to pathology reports identifying adenomatous polyps and modeled with multiple logistic regression. In adjusted models a >15 pack-year smoking history increased the likelihood of an adenoma (OR = 1.54, 95% CI 1.28–1.86), although ≤15 pack-years did not (OR = 1.07, 95% CI 0.87–1.32). Gender-stratified models showed a significantly increased risk of adenoma at lower smoking exposure even for men (OR = 1.32; 95% CI:1.00–1.76), but not for women (OR = 0.85; 95% CI:0.61–1.14). An ordered logistic regression model of adenoma occurrence showed a smoking history of ≥15 pack-years associated with 61% higher odds of adenoma at successively larger size categories (95% CI 1.34–1.93). For individuals with a family history of colorectal cancer, smoking does not further increase the risk of adenomas. Smoking duration is linked to occurrence and size of adenoma, especially for men.