Longitudinal study of muscle strength, quality, and adipose tissue infiltration
Longitudinal study of muscle strength, quality, and adipose tissue infiltration
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DOI：
10.3945/ajcn.2009.28047
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发表时间：
2009-12-01
影响因子：
7.1
通讯作者：
Goodpaster, Bret H.
中科院分区：
文献类型：
--
作者：
Delmonico, Matthew J.;Harris, Tamara B.;Goodpaster, Bret H.
背景：骨质疏松症被认为伴随着肌肉脂肪渗透的增加。然而，没有纵向研究研究老年人的肌肉质量、力量或脂肪渗透的伴随变化。目的：我们提供了与年龄相关的腿部成分、力量和肌肉质量(MQ)变化的纵向数据。我们假设肌肉横截面积(CSA)和力量将减少，肌肉脂肪渗透将在5年后增加。设计：在健康、老龄化和身体成分研究队列(n=1678)中，检查了大腿中段肌肉、皮下脂肪(SF)和肌间脂肪(IMF)CSA和等速腿部肌肉扭矩(MT/股四头肌CSA)。结果：男性MT损失16.1%，而女性MT损失13.4%。在那些体重减轻和体重保持稳定的人中，MT调整后的年化降幅是肌肉CSA损失的2-5倍。体重增加并没有阻止MT的减少，尽管肌肉CsA略有增加。只有体重增加的人SF增加(P<；0.001)，而体重减轻的人SF也减少(P<；0.001)。男性和女性与年龄相关(P<；0.001)，体重减轻、体重增加或体重保持不变的人(均为P<；0.001)，其MQ增加。结论：老年人腿部MT的损失大于肌肉CSA的损失，这表明MQ下降。此外，无论体重或SF的变化如何，衰老都与IMF的增加有关。AM J Clin Nutr 2009；90：1579-85。
Background: Sarcopenia is thought to be accompanied by increased muscle fat infiltration. However, no longitudinal studies have examined concomitant changes in muscle mass, strength, or fat infiltration in older adults.Objective: We present longitudinal data on age-related changes in leg composition, strength, and muscle quality (MQ) in ambulatory, well-functioning men and women. We hypothesized that muscle cross-sectional area (CSA) and strength would decrease and muscular fat infiltration would increase over 5 y.Design: Midthigh muscle, subcutaneous fat (SF), and intermuscular fat (IMF) CSAs and isokinetic leg muscle torque (MT) and MQ (MT/quadriceps CSA) were examined over 5 y in the Health, Aging, and Body Composition study cohort (n = 1678).Results: Men experienced a 16.1% loss of MT, whereas women experienced a 13.4% loss. Adjusted annualized decreases in MT were 2-5 times greater than the loss of muscle CSA in those who lost weight and in those who remained weight-stable. Weight gain did not prevent the loss of MT, despite a small increase in muscle CSA. Only those who gained weight had an increase in SF (P < 0.001), whereas those who lost weight also lost SF (P < 0.001). There was an age-related increase in IMF in men and women (P < 0.001), and IMF increased in those who lost weight, gained weight, or remained weight-stable (all P < 0.001).Conclusions: Loss of leg MT in older adults is greater than muscle CSA loss, which suggests a decrease in MQ. Additionally, aging is associated with an increase in IMF regardless of changes in weight or SF. Am J Clin Nutr 2009;90:1579-85.