Effects of local application of ototoxic antibiotics on cochlear potentials in guinea pigs.
Effects of local application of ototoxic antibiotics on cochlear potentials in guinea pigs.
复制标题
局部应用耳毒性抗生素对豚鼠耳蜗电位的影响。
作者：
T. Konishi
采用豚鼠局部灌流的方法，研究了新霉素、卡那霉素和双氢链霉素对豚鼠耳蜗微音素、听神经动作电位和耳蜗内电位的影响。当这些药物应用于内淋巴液时，会显着抑制耳蜗反应，但当应用于外淋巴液时，效果就较差。讨论了抗生素对Corti器官毛细胞的作用机制。
The effects of neomycin, kanamycin and dihydrostreptomycin on the cochlear microphonic, the action potential of the auditory nerve and the endocochlear potential were studied in guinea pigs in which these drugs were locally administered by perfusion. These drugs suppressed the cochlear responses markedly when applied to the endolymph but were less effective when applied to the perilymph. The mechanisms of action of antibiotics on the hair cells of the organ of Corti are discussed.