Blockade of Oxidized LDL-Triggered Endothelial Apoptosis by Quercetin and Rutin through Differential Signaling Pathways Involving JAK2
Blockade of Oxidized LDL-Triggered Endothelial Apoptosis by Quercetin and Rutin through Differential Signaling Pathways Involving JAK2
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DOI：
10.1021/jf803390m
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发表时间：
2009-03-11
影响因子：
6.1
通讯作者：
Kang, Young-Hee
中科院分区：
文献类型：
--
作者：
Choi, Jung-Suk;Kang, Sang-Wook;Kang, Young-Hee
氧化低密度脂蛋白是高度致动脉粥样硬化，因为它刺激泡沫细胞的形成，促进炎症和血栓形成过程。本研究阐明了抗氧化剂槲皮素及其芦丁苷是否在Cu2+氧化LDL暴露的内皮细胞中发挥抗凋亡作用。槲皮素和芦丁在无毒剂量下抑制氧化ldl诱导的内皮毒性
Oxidized LDL is highly atherogenic, as it stimulates foam cell formation and promotes inflammatory and thrombotic processes. The present study elucidated whether the antioxidants quercetin and its rutinoside rutin exert antiapoptosis in endothelial cells exposed to Cu2+-oxidized LDL. Quercetin and rutin inhibited the oxidized LDL-induced endothelial toxicity at nontoxic doses of