Molecular biology and biochemistry of the endothelins.
Molecular biology and biochemistry of the endothelins.
复制标题
内皮素的分子生物学和生物化学。
DOI：
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发表时间：
1989
影响因子：
13.8
通讯作者：
T. Masaki
中科院分区：
文献类型：
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作者：
M. Yanagisawa;T. Masaki
内皮素-1（ET-1）是新发现的哺乳动物内皮素生物活性肽家族的第一个成员，最初被鉴定为血管内皮细胞中的21个残基的有效血管收缩肽。然而，它已被证明在心血管系统内外的组织中具有多种药理活性，并且与 ET-1 惊人相似的肽已被发现是蛇毒的主要毒性成分。此外，最近的研究表明，包括人类在内的哺乳动物产生该肽家族的三个不同成员：ET-1、ET-2和ET-3，它们可能具有不同的生物活性特征，并且可能作用于内皮素受体的不同亚型。 Masashi Yanagisawa 和 Tomoh Masaki 综述了内皮素生物化学和分子生物学的现状。
Endothelin-1 (ET-1), the first member of the newly discovered mammalian endothelin family of biologically active peptides, was originally identified as a 21 residue potent vasoconstrictor peptide in vascular endothelial cells. However, it has since been demonstrated to possess a wide variety of pharmacological activities in tissues both within and outside the cardiovascular system, and peptides with a striking similarity to ET-1 have been found to be the major toxic component of a snake venom. Moreover, recent studies have suggested that mammals including humans produce three distinct members of this peptide family, ET-1, ET-2 and ET-3, which may have different profiles of biological activity, and may act on distinct subtypes of endothelin receptor. Masashi Yanagisawa and Tomoh Masaki review the current status of the biochemistry and molecular biology of endothelin.