New Horizons: Dietary protein, ageing and the Okinawan ratio
New Horizons: Dietary protein, ageing and the Okinawan ratio
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DOI：
10.1093/ageing/afw069
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发表时间：
2016-07-01
期刊：
影响因子：
6.7
通讯作者：
Simpson, Stephen J.
中科院分区：
文献类型：
--
作者：
Le Couteur, David G.;Solon-Biet, Samantha;Simpson, Stephen J.
营养对衰老和寿命有着深远的影响。热量限制是主要的营养干预，历史上已被证明会影响许多动物模型的寿命和/或健康寿命。研究表明，减少蛋白质摄入量也可以延长寿命，尽管不如限制热量那么显著。最近基于营养几何学的研究试图在广泛的膳食宏量营养素和能量含量范围内确定营养对衰老的影响。在昆虫和老鼠身上进行的研究表明，动物可以随意获得低蛋白、高碳水化合物的饮食，寿命最长。值得注意的是，实验动物衰老时膳食蛋白质与碳水化合物的最佳含量和比例与冲绳长寿者的传统饮食几乎相同。
Nutrition has profound effects on ageing and lifespan. Caloric restriction is the major nutritional intervention that historically has been shown to influence lifespan and/or healthspan in many animal models. Studies have suggested that a reduction in protein intake can also increase lifespan, albeit not as dramatically as caloric restriction. More recent research based on nutritional geometry has attempted to define the effects of nutrition on ageing over a broad landscape of dietary macronutrients and energy content. Such studies in insects and mice indicate that animals withad libitum access to low-protein, high-carbohydrate diets have longest lifespans. Remarkably, the optimum content and ratio of dietary protein to carbohydrates for ageing in experimental animals are almost identical to those in the traditional diets of the long-lived people on the island of Okinawa.