Reflections on Cancer in the Bone Marrow: Adverse Roles of Adipocytes.
Reflections on Cancer in the Bone Marrow: Adverse Roles of Adipocytes.
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DOI：
10.1007/s40610-017-0074-6
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发表时间：
2017-12
期刊：
影响因子：
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通讯作者：
Reagan MR
中科院分区：
文献类型：
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作者：
Falank C;Fairfield H;Reagan MR
这篇综述强调了我们对脂肪细胞在骨肿瘤发生或癌症疾病进展中的作用的理解的最新进展。在这篇综述中，我们的目的是描述骨髓脂肪组织，并讨论可溶性脂肪细胞衍生的细胞因子（脂肪因子）或内分泌因子，脂肪细胞衍生的脂质，和骨髓脂肪细胞和骨髓肿瘤细胞之间的实际或推定的阿曲他克林信号。这种关系可能影响肿瘤细胞的发生、增殖、转移和/或耐药性。骨髓脂肪可能影响肿瘤的增殖、耐药性或癌症引起的骨疾病，因此可能成为抗癌的新靶点。总体而言，关于骨髓脂肪和脂肪细胞在癌症进展中的作用的证据是混合的，并且需要在这个竞技场中进行更多的研究来确定这些骨髓微环境细胞如何促成骨髓中的恶性肿瘤，以确定新的、潜在的靶向途径。
This review highlights the recent advances in our understanding of adipocyte contributions to carcinogenesis or cancer disease progression for cancers in the bone. In this review, we aim to describe bone marrow adipose tissue and discuss the soluble adipocyte-derived cytokines (adipokines) or endocrine factors, adipocyte-derived lipids, and the actual or putative juxtacrine signaling between bone marrow adipocytes and tumor cells in the bone marrow. This relationship likely affects tumor cell initiation, proliferation, metastasis, and/or drug resistance. Bone marrow adipose may affect tumor proliferation, drug resistance, or cancer-induced bone disease and hence may be a new target in the fight against cancer. Overall, evidence is mixed regarding the role of bone marrow adipose and adipocytes in cancer progression, and more research in this arena is necessary to determine how these bone marrow microenvironmental cells contribute to malignancies in the marrow to identify novel, potentially targetable pathways.