In vivo response of porous hydroxyapatite and β-tricalcium phosphate prepared by aqueous solution combustion method and comparison with bioglass scaffolds
In vivo response of porous hydroxyapatite and β-tricalcium phosphate prepared by aqueous solution combustion method and comparison with bioglass scaffolds
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DOI：
10.1002/jbm.b.31009
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发表时间：
2008-07-01
影响因子：
3.4
通讯作者：
Basu, Debabrata
中科院分区：
文献类型：
--
作者：
Ghosh, Samir K.;Nandi, Samit K.;Basu, Debabrata
通过水溶液燃烧合成制备纯羟基磷灰石 (HAp) 和双相磷酸钙 [含有 90% β-磷酸三钙 (β-TCP) 和 10% HAp]。使用所有粉末以及生物玻璃（一种已知的生物活性材料）制备多孔支柱，并随后进行表征。将消毒的支柱植入 24 只雌雄黑孟加拉山羊的桡骨外侧，其中一组 6 个样本留有一个未填充的空白孔作为对照。使用扫描电子显微镜和组织学分析研究了三种植入材料的体内骨形成反应，并与阳性对照进行对比。推出测试用于评估骨-生物材料界面的机械强度。据观察，界面响应强烈依赖于不同物理和化学参数的组合。 β-TCP 的表面表现出与骨相似的特征，并且与生物玻璃中间磷灰石层的表面不同。与基于 β-TCP/生物玻璃的植入物相比，HAp 的骨向内生长较低且强度降低。 Ca-P 材料的骨形成反应根据植入材料的成分而变化，可以通过这种新颖的合成来定制。 (C) 2007 年 Wiley 期刊公司。
Pure hydroxyapatite (HAp) and a biphasic calcium phosphate [containing 90% of beta-tri-calcium phosphate (beta-TCP) and 10% HAp] were tailored through an aqueous solution combustion synthesis. Porous struts were prepared using all the powders along with bioglass, a known bioactive material, and subsequently characterized. Sterilized struts were implanted to the lateral side of radius bone of 24 black Bengal goats of either sex, in which a blank hole was left unfilled in a group of six specimens to act as control. The bone formation response of the three implanting materials in vivo has been studied using scanning electron microscope and histological analysis in contrast with positive controls. Push-out tests were used to assess the mechanical strength at the bone-biomaterial interface. It was observed that interfacial response was strongly dependent on combinations of different physical and chemical parameters. The surface of beta-TCP exhibited similar characteristics of bone and was distinct from those of intervening apatite layer of bioglass. Lower bone ingrowth and reduced strength was observed with HAp compared to beta-TCP/bioglass-based implants. Bone formation response of the Ca-P material varied according to the composition of the implanting material, which could be tailored through this novel synthesis. (C) 2007 Wiley Periodicals, Inc.