Selective matrix metalloproteinase inhibition with developing heart failure - Effects on left ventricular function and structure
Selective matrix metalloproteinase inhibition with developing heart failure - Effects on left ventricular function and structure
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DOI：
10.1161/01.res.0000052312.41419.55
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发表时间：
2003-02-07
影响因子：
20.1
通讯作者：
Spinale, FG
中科院分区：
文献类型：
--
作者：
King, MK;Coker, ML;Spinale, FG
基质金属蛋白酶（MMPs）是一个内源性蛋白水解酶家族，参与左心室重塑。然而，广谱MMP抑制（MMPi），特别是间质胶原酶（MMP-1）的抑制，可能不适用于临床。本研究检查了选择性MMP i（保留MMP-1）在发展中的充血性心力衰竭模型中的作用。将猪随机分为3组：（1）快速起搏3周（240 bpm，n=10）;（2）选择性MMPi（20 mg/kg/天-PO; PGE 7113313）和快速起搏（n=12）;（3）对照组（n=10）。与对照组相比，快速起搏组左室壁应力峰值增加（140+/-6 vs 319+/-18 g/cm（2）; P
The matrix metalloproteinases (MMPs) are an endogenous family of proteolytic enzymes implicated to contribute to LV remodeling. However, broad-spectrum MMP inhibition (MMPi), particularly inhibition of interstitial collagenase (MMP-1), may not be clinically applicable. This study examined the effects of selective MMPi (sparing MMP-1) in a model of developing congestive heart failure. Pigs were randomly assigned to 3 groups: (1) rapid pacing for 3 weeks (240 bpm, n=10); (2) selective MMPi (20 mg/kg per day-PO; PGE7113313) and rapid pacing (n=12); and (3) controls (n=10). LV peak wall stress increased from controls with rapid pacing (140+/-6 versus 319+/-18 g/cm(2); P