Synthesis of glucuronic acid derivatives via the efficient and selective removal of aC6 methyl group
Synthesis of glucuronic acid derivatives via the efficient and selective removal of aC6 methyl group
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高效选择性脱除αC6甲基合成葡萄糖醛酸衍生物
DOI：
10.1016/j.tetlet.2016.12.055
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发表时间：
2016
影响因子：
1.8
通讯作者：
郭春
中科院分区：
文献类型：
--
作者：
侯状;郭春
这项研究与合成某些葡萄糖醛酸衍生物的一般策略的开发有关。特别是，我们报告了用氢氧化钾去除 C6 甲基保护基团而不影响 C2、C3 和 C4 羟基上的苯甲酰基保护基团的特殊选择性条件，收率高（95-99%）。该方法反应时间短、收率高、产物单一，具有高效、环保的优点。
This investigation is related to the development of a general strategy for the synthesis of certain glucuronic acid derivatives. In particular, we report exceptionally selective conditions for removing the C6 methyl protecting group by potassium hydroxide without affecting the benzoyl protecting groups on the C2, C3 and C4 hydroxyl groups in high yields (95–99%). The present method proves to be efficient and environmentally friendly in terms of short reaction time, high yield and the single product.