Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease
Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease
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DOI：
10.1056/nejmoa043175
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发表时间：
2005-07-07
影响因子：
158.5
通讯作者：
Berger, PB
中科院分区：
文献类型：
--
作者：
Tsimikas, S;Brilakis, ES;Berger, PB
背景：脂蛋白（a）脂蛋白结合促炎氧化磷脂。我们研究了使用单克隆抗体E06测量的氧化低密度脂蛋白（LDL）水平是否反映了阻塞性冠状动脉疾病的存在和程度，阻塞性冠状动脉疾病定义为狭窄超过管腔直径的50%。方法：在冠状动脉造影术前测量了504例患者的氧化LDL和Lp（a）脂蛋白水平。氧化型低密度脂蛋白的水平报告为每粒载脂蛋白B-100的氧化磷脂含量（氧化磷脂：载脂蛋白B-100比值）。结果：氧化磷脂：载脂蛋白B-100比值和Lp（a）脂蛋白水平的测量值向低值倾斜，氧化磷脂：载脂蛋白B-100比值与Lp（a）脂蛋白的测量值密切相关（r=0.83，P
Background: Lp(a) lipoprotein binds proinflammatory oxidized phospholipids. We investigated whether levels of oxidized low-density lipoprotein (LDL) measured with use of monoclonal antibody E06 reflect the presence and extent of obstructive coronary artery disease, defined as a stenosis of more than 50 percent of the luminal diameter.Methods: Levels of oxidized LDL and Lp(a) lipoprotein were measured in a total of 504 patients immediately before coronary angiography. Levels of oxidized LDL are reported as the oxidized phospholipid content per particle of apolipoprotein B-100 (oxidized phospholipid:apo B-100 ratio).Results: Measurements of the oxidized phospholipid:apo B-100 ratio and Lp(a) lipoprotein levels were skewed toward lower values, and the values for the oxidized phospholipid:apo B-100 ratio correlated strongly with those for Lp(a) lipoprotein (r=0.83, P