Infant diurnal cortisol predicts sleep.
Infant diurnal cortisol predicts sleep.
复制标题
婴儿昼间皮质醇可预测睡眠。
DOI：
10.1111/jsr.13357
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发表时间：
2021
影响因子：
4.4
通讯作者：
Tarullo,AmandaR
中科院分区：
文献类型：
--
作者：
Tuladhar,CharuT;Schwartz,Sophie;StJohn,AshleyM;Meyer,JerroldS;Tarullo,AmandaR
睡眠-觉醒系统在出生时并不成熟，与下丘脑-垂体-肾上腺轴平行发育，下丘脑-垂体-肾上腺轴是一种生物应激系统，其最终产物是皮质醇。婴儿期一个系统的扰动可能会不适应地影响另一个系统的成熟，导致持久的睡眠和皮质醇系统失调，并增加持续健康问题的风险。为了更好地理解这些系统之间的早期相互作用，我们检查了在12个月大的儿童中，由体动计衍生的夜间睡眠持续时间和开始的测量是否与皮质醇的累积暴露相关，以头发皮质醇浓度为指标。总的来说，早睡预示着较低的头发皮质醇超过睡眠时间，家庭收入和混乱的家庭经历。此外，睡眠和皮质醇水平每天都在变化，日常睡眠和皮质醇调节之间的时间依赖性还没有得到很好的理解。因此，我们评估了特定晚上的睡眠特征如何与第二天的唾液皮质醇水平相关，以及白天和晚上的皮质醇如何与同一晚上的睡眠特征相关。在特定的一天，皮质醇的总暴露量较低与同一晚上较长的夜间睡眠时间有关，但与睡眠开始无关。在一个特定的夜晚，唾液皮质醇水平较低与当天晚上较早的睡眠有关，但与夜间睡眠时间无关。睡眠持续时间和发作在一个给定的夜晚是无关的总皮质醇暴露的第二天。研究结果表明，在早期发育中，睡眠和皮质醇之间的日常关系不是双向的，而是由昼夜皮质醇驱动的。
The sleep–wake system is immature at birth and develops in parallel with the hypothalamic–pituitary–adrenal axis, a biological stress system of which the end product is cortisol. Perturbations in one system during infancy can maladaptively influence the maturation of the other system, leading to lasting sleep and cortisol system dysregulation and heightening the risk of enduring health problems. To better understand the early interplay between these systems, we examined whether actigraphy‐derived measures of night‐time sleep duration and onset were associated with cumulative exposure to cortisol, indexed by hair cortisol concentration, in 12‐month‐old children. Overall, early sleep onset predicted lower hair cortisol above and beyond sleep duration, family income and chaos experienced at home. Furthermore, both sleep and cortisol levels vary day to day, and temporal dependencies between daily sleep and cortisol regulation are not well understood. Thus, we assessed how the sleep characteristics on a particular evening related to salivary cortisol levels the following day and how daytime and evening cortisol related to the sleep characteristics on the same night. Lower total exposure to cortisol on a particular day was related to longer night‐time sleep duration the same night, but not sleep onset. Lower salivary cortisol levels on a given evening related to earlier sleep onset the same night, but not to night‐time sleep duration. Sleep duration and onset on a given night were unrelated to total cortisol exposure the following day. Findings suggest that in early development, the day‐to‐day relation between sleep and cortisol is not bidirectional, but more driven by diurnal cortisol.