The molecular basis and prospects in pancreatic development
The molecular basis and prospects in pancreatic development
复制标题
胰腺发育的分子基础和前景
DOI：
10.1111/j.1440-169x.2005.00813.x
复制
发表时间：
2005
期刊：
影响因子：
4.6
通讯作者：
S. Kume
中科院分区：
文献类型：
--
作者：
S. Kume
Studies on the signaling mechanism that control the specification of endoderm‐derived organs have only recently begun. While many studies revealed genes involved in the differentiation, growth and morphogenesis of the pancreas through studies of mutant mice, still little is known about how endoderm give rise to specific domains. Although many genes are known to have a role in pancreatic differentiation, growth and morphogenesis, few genes are known to take part in the specification of the pancreas so far. Hallmarks as well as gene markers for early development of the pancreas, which are however still very limited, will be useful for dissecting early events in pancreatic specification. Here, I give a summary on the origin of the dorsal and ventral pancreatic progenitors, signals for inductions, and genes so far known to function in pancreatic differentiation. I also give a future prospect in the use of ES cells and other experimental models, towards a comprehensive understanding of gene networks in the progenitor cells or intermediate cell types which arise during various stages of differentiation.
登录
查看更多内容
影响因子：
4.8
作者：
Chakrabarti, SK;James, JC;Mirmira, RG
通讯作者：
Mirmira, RG
影响因子：
10.5
作者：
Rossi, JM;Dunn, NR;Zaret, KS
通讯作者：
Zaret, KS
影响因子：
7.7
作者：
Jensen, J;Heller, RS;Serup, P
通讯作者：
Serup, P
影响因子：
4.6
作者：
Gail Deutsch;Joo-Un Jung;Minghua Zheng;J. Lora;K. Zaret
通讯作者：
Gail Deutsch;Joo-Un Jung;Minghua Zheng;J. Lora;K. Zaret
影响因子：
4.6
作者：
L. Sussel;J. Kalamaras;D. Hartigan-O’Connor;J. Meneses;R. Pedersen;J. Rubenstein;M. German
通讯作者：
L. Sussel;J. Kalamaras;D. Hartigan-O’Connor;J. Meneses;R. Pedersen;J. Rubenstein;M. German