Physiological response of mouse retinal ganglion cells to electrical stimulation: effect of soma size.
Physiological response of mouse retinal ganglion cells to electrical stimulation: effect of soma size.
复制标题
DOI：
10.1109/iembs.2011.6090252
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Weiland JD
中科院分区：
文献类型：
--
作者：
Cho AK;Sampath AP;Weiland JD
视网膜前假体旨在通过电刺激受光感受器退行性疾病（例如年龄相关性黄斑变性（AMD）和色素性视网膜炎（RP））患者的视网膜神经节细胞（RGC）来恢复功能性视力。在视网膜变性期间，感光细胞死亡后，视网膜内部细胞发生明显的重塑和重新布线。尽管发生了这些变化，相当多的 RGC 群体仍然能够接受假体刺激。为了选择性地靶向 RGC 的局部子集，需要更好地了解这些细胞的解剖和生理特性。此外，需要评估视网膜变性引起的电兴奋性的潜在改变。本研究探讨了 RGC 胞体大小对动作电位（尖峰）产生阈值的影响及其对视觉功能挽救的影响。
An epiretinal prosthesis aims to restore functional vision by stimulating electrically the retinal ganglion cells (RGCs) in patients affected by photoreceptor degenerative diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). During retinal degeneration, photoreceptor death is followed by pronounced remodeling and rewiring of inner retinal cells. Despite these changes, a considerable population of RGCs remain receptive to prosthetic stimulation. To target selectively a localized subset of RGCs, an improved understanding of the anatomical and physiological properties of these cells is required. Additionally, potential alterations in electrical excitability produced by the retinal degeneration needs to be assessed. This study investigates the effect of RGC soma size on the threshold for action potential (spike) generation and its implications for the rescue of visual function.