Opinion - The role of apoptosis in cancer development and treatment response
Opinion - The role of apoptosis in cancer development and treatment response
复制标题
DOI：
10.1038/nrc1560
复制
发表时间：
2005-03-01
影响因子：
78.5
通讯作者：
Attardi, LD
中科院分区：
文献类型：
--
作者：
Brown, JM;Attardi, LD
程序性细胞死亡或凋亡的失活是癌症发展的核心。这种凋亡反应的失能可能是治疗抗性和观察结果的主要贡献者，在许多肿瘤中，凋亡不是响应于常见治疗方案的癌细胞死亡的主要机制。重要的是，这表明其他细胞死亡模式也参与了对治疗的反应。
The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. This disabling of apoptotic responses might be a major contributor both to treatment resistance and to the observation that, in many tumours, apoptosis is not the main mechanism for the death of cancer cells in response to common treatment regimens. Importantly, this suggests that other modes of cell death are involved in the response to therapy.