CELLULAR ORIGINS OF THE FETAL-HÆMOGLOBIN-CONTAINING CELLS OF NORMAL ADULTS
CELLULAR ORIGINS OF THE FETAL-HÆMOGLOBIN-CONTAINING CELLS OF NORMAL ADULTS
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正常成人含胎儿血红蛋白的细胞的细胞起源
DOI：
10.1016/s0140-6736(79)91844-0
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
J. Adamson
中科院分区：
文献类型：
--
作者：
C. Bunch;W. Wood;D. Weatherall;J. Adamson
研究了含Hb F （F细胞）的小群成人红细胞的起源，研究了一种克隆性造血障碍，多红细胞rubra vera （P.R.V.）。在11名未接受细胞毒性治疗的患者中，f细胞占循环红细胞的比例< 0.1%至11.9%，而在21 h病理学正常对照组中，f细胞占循环红细胞的比例为0.34%至4.6%。另外2例患者为葡萄糖-6-磷酸脱氢酶杂合子，可以直接证明P.R.V.的克隆性；f细胞值分别为2.1%和8.3%。这些观察结果表明，f细胞与其他成体红细胞一样来自同一群干细胞，而不是来自一个单独的干细胞库。
The origin of the small population of adult red cells which contain Hb F (F-cells) has been studied in a clonal disorder of hæmopoiesis, polycythæmia rubra vera (P.R.V.). In eleven patients who had not received cytotoxic therapy F-cells comprised <0·1% to 11·9% of the circulating red cells, compared with 0·34% to 4·6% in 21 hæmatologically normal controls. Two additional patients were glucose-6-phosphate-dehydrogenase heterozygotes in whom the clonal nature of the P.R.V. could be demonstrated directly; they had F-cell values of 2·1% and 8·3%. These observations indicate that F-cells arise from the same population of stem cells as other adult red cells and not from a separate stem-cell pool.