Metal catalyzed hydrometalations and their applications in synthesis
Metal catalyzed hydrometalations and their applications in synthesis
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DOI：
10.1351/pac199870051059
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发表时间：
1998-05-01
影响因子：
1.8
通讯作者：
Ostrovsky, D
中科院分区：
文献类型：
--
作者：
Lautens, M;Rovis, T;Ostrovsky, D
我们报告说，钯催化的联烯氢锡化会产生烯丙基锡烷或乙烯基锡烷，具体取决于催化剂的选择。还研究了1，6-二炔的氢化锡化反应，并显示出具有（Z）立体化学的带有锡基团的1，2-亚烷基环戊烷。讨论了金属离子和配体的影响。最后，一个对映选择性镍催化还原开环三类氧杂双环底物已被开发和方法已被应用到舍曲林，一个商业上重要的抗抑郁药的合成。
We report that palladium catalyzed hydrostannation of allenes leads to allylstannanes or vinylstannanes depending on the choice of catalyst. Hydrostannation of 1,6-diynes has also been investigated and shown to give 1,2-alkylidenecyclopentanes bearing a tin group with (Z) stereochemistry. The effect of metal and ligand is discussed. Finally, an enantioselective nickel catalyzed reductive ring opening of three classes of oxabicyclic substrates has been developed and the methodology has been applied to the synthesis of sertraline, a commercially important antidepressant.