Current challenges and recent advances in the search for a cure for HIV.
Current challenges and recent advances in the search for a cure for HIV.
复制标题
寻找艾滋病毒治疗方法的当前挑战和最新进展。
DOI：
10.1002/jia2.25248
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发表时间：
2019
影响因子：
6
通讯作者：
Jones,RBrad
中科院分区：
文献类型：
--
作者：
Jones,RBrad
尽管现代抗逆转录病毒 (ARV) 疗法能够持久地将 HIV 复制抑制到不可检测的水平，但它们无法治愈感染。如果治疗中断，病毒会从感染艾滋病毒的细胞中迅速反弹。因此，艾滋病毒治疗研究的一个基本目标是开发能够靶向和消除病毒库的新疗法，这可能使个体停止抗逆转录病毒治疗而不会出现病毒反弹。在这里，我们提出了与此目标相关的两个关键挑战和进步领域的观点。
Although modern antiretroviral (ARV) therapies durably suppress HIV replication to undetectable levels, they are unable to cure infection. If therapy is ever interrupted, virus rapidly rebounds from persistent reservoirs of cells infected with HIV. A fundamental goal of HIV cure research is thus to develop novel therapies capable of targeting and eliminating viral reservoirs, which may allow individuals to stop ARV therapy without viral rebound. Here, we present a perspective on two key areas of challenge and advancement in relation to this goal.