Theory of porous catheters and their applications in intraparenchymal infusions.
Theory of porous catheters and their applications in intraparenchymal infusions.
复制标题
多孔导管理论及其在实质内输注中的应用。
DOI：
10.1088/2057-1976/aa5a77
复制
发表时间：
2017
影响因子：
1.4
通讯作者：
Odland,RickM
中科院分区：
文献类型：
--
作者：
Raghavan,Raghu;Odland,RickM
多端口导管和具有多孔表面的导管已经被提出用于在流体悬浮液中的治疗剂的实质内输注。目标疾病包括脑癌和严重的神经退行性疾病，以及外周肿瘤，例如前列腺和肝脏中的肿瘤。我们建立了从这样的设备，特别是流体流动方程，需要导管内的流动和组织中的流动之间的耦合输注的理论。(Such在从单端口导管输注的理论中耦合不是必需的）。这种导管的新功能，处理我们的模型，揭示了注入到不均匀的介质。多端口设计具有克服单端口导管的限制的潜力，对于单端口导管，流体离开端口的路径由不均匀性支配。我们解决这些方程的一些简单的情况下，说明多孔导管的关键设计特点，显示这样的优势。还开发了具有更现实假设的数值解所需的数学。我们证实了这种导管的鲁棒性，当端口具有足够的阻力时，可以防止泄漏路径影响具有一个或几个大端口的导管的输注。本文的方法可以纳入涉及此类设备的脑实质内输液的更大规划系统中。
Multiport catheters and catheters with a porous surface have been proposed for intraparenchymal infusions of therapeutics in fluid suspensions. Target diseases include brain cancer and serious neurodegenerative diseases, as well as peripheral tumors, for example in the prostate and the liver. We set up the theory for infusions from such devices, in particular the fluid flow equations which demand a coupling between the flow within the catheter and that in tissue.(Such a coupling is not necessary in the theory of infusion from single port catheters.) The new feature of such catheters, treated by our model, is revealed by infusions into inhomogeneous media. Multiport designs have the potential to overcome the limitation of single port catheters, for which the path of the fluid leaving the port is dominated by the inhomogeneities. We solve these equations for some simple cases to illustrate the key design features of porous catheters that show such advantages. The mathematics required for numerical solution with more realistic assumptions is also developed. We confirm the robustness of such catheters, when the ports are sufficiently resistive, against leakage paths that would compromise the infusions from catheters with one or a few large ports. The methods of this paper can be incorporated into a larger planning system for intraparenchymal infusions involving such devices.