Pediatric Global Health in Children with Very Early-Onset Inflammatory Bowel Disease.
Pediatric Global Health in Children with Very Early-Onset Inflammatory Bowel Disease.
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患有极早发炎症性肠病的儿童的儿科全球健康。
DOI：
10.1093/jpepsy/jsab035
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发表时间：
2021
影响因子：
3.6
通讯作者：
Kelsen,JudithR
中科院分区：
文献类型：
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作者：
Holbein,ChristinaE;Plevinsky,Jill;Patel,Trusha;Conrad,MaireC;Kelsen,JudithR
目的极早发性炎症性肠病 (VEO-IBD) 儿童是一组独特的 IBD 患者，具有独特的表型和遗传特征；然而，它们经常被心理社会研究忽略。本研究使用了一种新颖、简短的儿科全球健康测量方法来评估 (1) VEO-IBD 儿童的总体健康相关生活质量 (HRQOL)，(2) 与健康儿童相比的 HRQOL，以及 (3) 胃肠道症状是否是这些组之间 HRQOL 差异的原因。 方法 51 名 VEO-IBD 儿童（Mage = 4.26 岁，75% 男性）和 54 名健康儿童的看护者 （法师 = 3.50 岁，54% 男性）完成了 PROMIS 儿科全球健康量表 (PGH-7) 家长代理表以评估 HRQOL 和评估胃肠道症状的问卷。进行了描述性统计、协变量方差分析 (ANCOVA) 以及引导冥想分析。 结果 VEO-IBD 儿童的护理人员将其 HRQOL 评为相对积极，尽管病情较重的儿童在某些 PGH-7 项目上的评分较低（例如与朋友相处的乐趣、身体健康、悲伤）。与健康青少年相比，患有 VEO-IBD 的儿童在 PGH-7 上的得分较低，在整体健康、身体健康、心理健康和生活质量方面的项目级别得分显着较低。胃肠道症状介导了健康状况（即 VEO-IBD 与健康）和 HRQOL 之间的关联，αβ= -2.84，95% CI = -5.70，-0.34。 结论 虽然一些患有 VEO-IBD 的儿童存在 HRQOL 缺陷的风险，但许多儿童的恢复能力相当强。心理社会筛查对于为 VEO-IBD 儿童提供适当的行为健康服务转介和了解更多有关心理社会调整的信息是必要的。
ObjectiveChildren with very early-onset inflammatory bowel disease (VEO-IBD) represent a distinct group of patients with IBD with unique phenotypic and genetic characteristics; however, they are frequently omitted from psychosocial research. This study used a novel, brief measure of pediatric global health to assess (1) overall health-related quality of life (HRQOL) in children with VEO-IBD, (2) HRQOL compared to healthy children, and (3) whether gastrointestinal symptoms account for the differences in HRQOL between these groups.MethodsCaregivers of 51 children with VEO-IBD (Mage= 4.26 years, 75% male) and 54 healthy children (Mage= 3.50 years, 54% male) completed the PROMIS Pediatric Global Health Scale (PGH-7) parent-proxy form to assess HRQOL and a questionnaire assessing gastrointestinal symptoms. Descriptive statistics, analysis of variance with covariates (ANCOVA), and meditation analyses with bootstrapping were conducted.ResultsCaregivers of children with VEO-IBD rated their HRQOL as relatively positive, although children with greater disease yielded lower ratings on some PGH-7 items (e.g., fun with friends, physical health, sadness). Compared to healthy youth, children with VEO-IBD scored lower on the PGH-7, with significantly lower item-level scores on overall health, physical health, mental health, and quality of life. Gastrointestinal symptoms mediated the association between health status (i.e., VEO-IBD vs. healthy) and HRQOL,αβ= −2.84, 95% CI = −5.70, −0.34.ConclusionsWhile some children with VEO-IBD are at risk for deficits in HRQOL, many are quite resilient. Psychosocial screening is necessary for providing appropriate referrals to behavioral health services and learning more about psychosocial adjustment in children with VEO-IBD.