DRD4 related to infant attention and information processing: a developmental link to ADHD?
DRD4 related to infant attention and information processing: a developmental link to ADHD?
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DOI：
10.1097/00041444-200103000-00006
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发表时间：
2001-03-01
影响因子：
0.9
通讯作者：
Ebstein, R
中科院分区：
文献类型：
--
作者：
Auerbach, JG;Benjamin, J;Ebstein, R
多巴胺D4受体（DRD 4）外显子III多态性引起了人们的兴趣，因为它与注意缺陷多动障碍（ADHD）有关，ADHD儿童中7个重复等位基因的频率增加。注意力和信息处理的持续缺陷是ADHD的特征，这些功能的个体差异从婴儿期就很明显。我们发现，在结构化游戏情境和信息处理任务中，携带7-DRD 4等位基因的1岁婴儿比不携带7-DRD 4等位基因的婴儿表现出更少的持续注意力和新奇偏好，DRD 4和5-羟色胺转运体启动子之间也存在显著的相互作用（5-HTTLPR）基因对持续性注意的影响，我们的研究结果为DRD 4和ADHD之间可能通过早期持续性注意和信息加工的发育联系提供了证据。它还指出了在行为研究中考虑多个基因的影响的重要性，Psychiatr Genet 11：31-35（C）2001 Lippincott威廉姆斯& Wilkins。
The dopamine D4 receptor (DRD4) exon III polymorphism has generated interest because of its association with attention deficit hyperactivity disorder (ADHD), with an increased frequency of the seven-repeat allele being reported in children with ADHD. Deficits in sustained attention and information processing characterize ADHD, and individual differences in these functions are apparent from infancy. We found that in a structured play situation and on an information-processing task, 1-year-old infants with the 7-DRD4 allele showed less sustained attention and novelty preference than do infants without the 7-DRD4 allele, There was also a significant interaction between DRD4 and the serotonin transporter promoter (5-HTTLPR) gene on a measure of sustained attention, Our results provide evidence for a possible developmental link between DRD4 and ADHD via early sustained attention and information processing. It also points to the importance of considering the influence of more than one gene in studies of behavior, Psychiatr Genet 11:31-35 (C) 2001 Lippincott Williams & Wilkins.