Topographical connections of the substantia nigra pars reticulata to higher-order thalamic nuclei in the rat
Topographical connections of the substantia nigra pars reticulata to higher-order thalamic nuclei in the rat
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DOI：
10.1016/j.brainresbull.2011.11.005
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发表时间：
2012-02-10
影响因子：
3.8
通讯作者：
Cavdar, Safiye
中科院分区：
文献类型：
--
作者：
Gulcebi, Medine Idrizoglu;Ketenci, Sema;Cavdar, Safiye
黑质网状部（SNR）是黑质的腹侧分部，主要含有GABA能神经元。本研究探讨SNR是否涉及所有丘脑背核等同或只是一组特定的核团，如第一或高阶nucleus.injections的生物素化葡聚糖胺（BDA）的10只雄性成年大鼠的SNR。记录了顺行标记的轴突终末在丘脑核团中的分布。的SNR丘脑核团的预测是专门的一些电机高阶，但不是一阶丘脑继电器。双侧投射至腹内侧核（VM）、束旁核（PF）、中央正中核（CM）和中央旁核（PC），单侧投射至中央外侧核（CL）、背内侧核（MD）和丘脑网状核（Rt）。标记的轴突终末在丘脑核的范围从众多到稀疏的VM，PF，CM，CL，PC，MD和RT。此外，注射到SNR沿着其喙尾轴表现出特定的地形连接与丘脑核。头侧注射SNR显示VM、PF、CL、PC、CM、MD和Rt的标记轴突终末，尾侧注射SNR显示VM、PF、PC、CM和MD的标记轴突终末。黑质丘脑GABA能神经元可被认为是调节运动活动的重要系统。SNR能够通过直接或经由Rt间接调节一些运动高级丘脑核团来影响新皮层的大区域。（C）2011 Elsevier Inc. All rights reserved.
The substantia nigra pars reticulata (SNR) is the ventral subdivision of the substantia nigra and contains mostly GABAergic neurons. The present study explores whether the SNR relates to all dorsal thalamic nuclei equally or just to a particular group of nuclei, such as first or higher-order nuclei.Injections of biotinylated dextran amine (BDA) were made into the SNR of 10 male adult rats. The distribution of anterogradely labelled axon terminals in the thalamic nuclei was documented. The projections of the SNR to the thalamic nuclei were exclusively to some motor higher-order, but not to first-order thalamic relays. There were bilateral projections to the ventromedial (VM), parafascicular (PF), centromedian (CM) and paracentral (PC) nuclei and unilateral projections to the centrolateral (CL), mediodorsal (MD) and thalamic reticular nucleus (Rt). Labelled axon terminals in the thalamic nuclei ranged from numerous to sparse in VM, PF, CM, CL, PC, MD and Rt. Further, injections into the SNR along its rostral-caudal axis showed specific topographical connections with the thalamic nuclei. The rostral SNR injections showed labelled axon terminals of VM, PF, CL, PC, CM, MD and Rt. Caudal SNR injections showed labelling of VM, PF, PC, CM and MD. All injections showed labelled axons and terminals in the zona incerta.The nigrothalamic GABAergic neurons can be regarded as an important system for the regulation of motor activities. The SNR is in a position to influence large areas of the neocortex by modulating some of the motor higher-order thalamic nuclei directly or indirectly via Rt. (C) 2011 Elsevier Inc. All rights reserved.