Predominant treatment failure in postprostatectomy patients is local: Analysis of patterns of treatment failure in SWOG 8794
Predominant treatment failure in postprostatectomy patients is local: Analysis of patterns of treatment failure in SWOG 8794
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DOI：
10.1200/jco.2006.09.6495
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发表时间：
2007-06-01
影响因子：
45.3
通讯作者：
Crawford, E. David
中科院分区：
文献类型：
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作者：
Swanson, Gregory P.;Hussey, Michael A.;Crawford, E. David
西南肿瘤学组织(SWOG)8794号试验表明，与单纯根治性前列腺切除术相比，辅助放射治疗可将生化(前列腺特异性抗原[PSA])治疗失败的风险降低50%。在这项分析中，我们根据患者的放射前PSA水平进行分层，并将其与PSA治疗失败、局部复发和远处失败等结果相关联，以作为未来研究的指南。患者与方法431名病理晚期前列腺癌患者(前列腺癌外延、手术切缘阳性或精囊侵犯)被随机分配到辅助放射治疗或观察中。结果374名符合条件的患者立即接受了前列腺切除术后的PSA数据和随访。中位随访期为10.2年。对于术后PSA为
PurposeSouthwest Oncology Group (SWOG) trial 8794 demonstrated that adjuvant radiation reduces the risk of biochemical (prostate-specific antigen [PSA]) treatment failure by 50% over radical prostatectomy alone. In this analysis, we stratified patients as to their preradiation PSA levels and correlated it with outcomes such as PSA treatment failure, local recurrence, and distant failure, to serve as guidelines for future research.Patients and MethodsFour hundred thirty-one subjects with pathologically advanced prostate cancer (extraprostatic extension, positive surgical margins, or seminal vesicle invasion) were randomly assigned to adjuvant radiotherapy or observation.ResultsThree hundred seventy-four eligible patients had immediate postprostatectomy and follow-up PSA data. Median follow-up was 10.2 years. For patients with a postsurgical PSA of