Blood vessels form a scaffold for neuroblast migration in the adult olfactory bulb
Blood vessels form a scaffold for neuroblast migration in the adult olfactory bulb
复制标题
DOI：
10.1523/jneurosci.0678-07.2007
复制
发表时间：
2007-05-30
影响因子：
5.3
通讯作者：
Puche, Adam C.
中科院分区：
文献类型：
--
作者：
Bovetti, Serena;Hsieh, Yi-Chun;Puche, Adam C.
在整个发育过程中和成人中，新细胞不断添加到啮齿动物嗅球（OB）中。这些细胞从室管膜下区沿沿着吻侧迁移流切向迁移到OB，在OB中它们从OB中心向外周径向迁移。尽管在其他脑区已经描述了不同形式的放射状迁移，但在OB中控制放射状迁移的机制仍然是未知的。在这里，我们确定了一种新的迁移方式，其中神经元前体迁移沿着血管向其目的地。我们的研究结果表明，一半的放射状迁移细胞与OB颗粒细胞层中的血管系统相关，体内延时成像表明它们通过与细胞外基质和血管周围星形胶质细胞的相互作用，使用血管作为迁移的支架。末端脚。目前的数据提供的证据表明，一种新的迁移方式，亲血管性迁移，发生在成年人的大脑，并揭示了一个新的作用，脑血管。
New cells are continuously added to the rodent olfactory bulb (OB), throughout development and in adults. These cells migrate tangentially from the subventricular zone along the rostral migratory stream to the OB, where they migrate radically from the center to periphery of the OB. Although different modalities of radial migration have been described in other brain regions, the mechanisms governing radial migration in the OB are still mostly unknown. Here, we identify a new modality of migration in which neuronal precursors migrate along blood vessels toward their destination. Our results show that half of the radially migrating cells associate with the vasculature in the granule cell layer of the OB, and in vivo time-lapse imaging demonstrates that they use blood vessels as a scaffold for their migration through an interaction with the extracellular matrix and perivascular astrocyte end feet. The present data provide evidence that a new modality of migration, vasophilic migration, is occurring in the adult brain and reveals a novel role of brain vasculature.