Assessment of human brain water content by cerebral bioelectrical impedance analysis: A new technique and its application to cerebral pathological conditions
Assessment of human brain water content by cerebral bioelectrical impedance analysis: A new technique and its application to cerebral pathological conditions
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DOI：
10.1097/00006123-200205000-00023
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发表时间：
2002-05-01
期刊：
影响因子：
4.8
通讯作者：
Tomasello, F
中科院分区：
文献类型：
--
作者：
Grasso, G;Alafaci, C;Tomasello, F
目的：脑含水量的变化在一些脑病理条件和脑含水量的测量是重要的，以选择适当的治疗程序。我们提出了一种定量的，在体内，生物电阻抗分析（BIA）的方法，并提出其使用的准确评估人类subjects.METHODS之间的脑水含量：脑BIA是基于在脑实质中的一个施加电流的传导。通过放置在眼睑上的两个电极在50 kHz下施加800 μ A的激发电流，同时闭上眼睛，并用放置在枕下区的两个电极检测电压降，从而可以测量脑电阻和电抗。通过考虑颅周和阻力的方程，可以量化总脑含水量，表示为生物电体积。对一系列健康志愿者（n = 100）进行脑BIA，以测定平均脑含水量值。然后将该方法应用于50例脑肿瘤（n = 20），颅内出血（n = 16），或脑积水（n = 14），用于评估全球脑水含量的变化。结果：两组比较有显著性差异（P < 0.001）。健康志愿者的平均脑含水量值（表示为生物电体积值）为38.2 +/- 3.9 cm（2）/Ω，脑病理状态患者为67.7 +/- 13.1 cm（2）/Ω。结论：本研究结果表明，BIA应用于脑实质是一种有效的方法，可以预测正常和病理状态下的脑含水量。然而，需要进一步的研究来确定它是否足够敏感和可靠，以用于未来的临床应用。
OBJECTIVE: Total brain water content changes in several cerebral pathological conditions and the measurement of brain water content are important for the selection of appropriate therapeutic procedures. We present a quantitative, in vivo, bioelectrical impedance analysis (BIA) method and propose its use for the accurate assessment of brain water content among human subjects.METHODS: Cerebral BIA is based on the conduction of an applied current in the brain parenchyma. Application of an excitatory current of 800 muA at 50 kHz, via two electrodes placed on the eyelids with the eyes closed, and detection of the voltage drop with two electrodes placed in the suboccipital region allow brain resistance and reactance to be measured. By means of an equation that considers cranial circumference and resistance, it is possible to quantify the total brain water content, expressed as the bioelectrical volume. Cerebral BIA was performed with a series of healthy volunteers (n = 100), for determination of average brain water content values. The method was then applied to 50 patients with brain tumors (n = 20), intracranial hemorrhage (n = 16), or hydrocephalus (n = 14), for assessment of changes in global brain water contents. Data were compared with those obtained for healthy volunteers.RESULTS: Statistically significant differences (P < 0.001) were observed between the two groups. Mean brain water content values (expressed as bioelectrical volume values) were 38.2 +/- 3.9 cm(2)/Omega for healthy volunteers and 67.7 +/- 13.1 cm(2)/Omega for patients with cerebral pathological conditions. Statistically significant differences (P < 0.05) were also observed among patients with cerebral pathological conditions.CONCLUSION: The results of this study suggest that BIA, applied to the cerebral parenchyma, is a valid method for the prediction of brain water contents under both normal and pathological conditions. However, further studies are needed to establish whether it is sensitive and reliable enough for future clinical applications.