Longitudinal Assessment of Chemotherapy-Induced Alterations in Brain Activation During Multitasking and Its Relation With Cognitive Complaints
Longitudinal Assessment of Chemotherapy-Induced Alterations in Brain Activation During Multitasking and Its Relation With Cognitive Complaints
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DOI：
10.1200/jco.2013.53.6219
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发表时间：
2014-07-01
影响因子：
45.3
通讯作者：
Sunaert, Stefan
中科院分区：
文献类型：
--
作者：
Deprez, Sabine;Vandenbulcke, Mathieu;Sunaert, Stefan
目的探讨乳腺癌治疗后认知功能障碍与多任务处理过程中脑活动变化的关系。患者与方法18例计划接受化疗的患者在治疗开始前(T1)和治疗结束后4~6个月(T2)在扫描仪中进行了功能磁共振成像多任务任务。16名未计划接受化疗的患者和17名匹配的健康对照组在匹配的时间间隔执行相同的任务。任务难度水平被单独调整，以匹配不同参与者的表现。结果基于体素的配对t检验显示，在化疗患者的多任务网络中，从T1到T2的激活显著减少(P<；.05)，而在两个对照组中都没有发现变化。在基线时，两组之间没有差异。此外，与对照组相比，接受化疗的患者报告的认知主诉显著增加(P
Purpose To examine whether cognitive complaints after treatment for breast cancer are associated with detectable changes in brain activity during multitasking.Patients and Methods Eighteen patients who were scheduled to receive chemotherapy performed a functional magnetic resonance imaging multitasking task in the scanner before the start of treatment (t1) and 4 to 6 months after finishing treatment (t2). Sixteen patients who were not scheduled to receive chemotherapy and 17 matched healthy controls performed the same task at matched intervals. Task difficulty level was adjusted individually to match performance across participants. Statistical Parametric Mapping 8 (SPM8) software was used for within-group, between-group, and groupby- time interaction image analyses.Results Voxel-based paired t tests revealed significantly decreased activation (P < .05) from t1 to t2 at matched performance in the multitasking network of chemotherapy-treated patients, whereas no changes were noted in either of the control groups. At baseline, there were no differences between the groups. Furthermore, in contrast to controls, the chemotherapy-treated patients reported a significant increase in cognitive complaints (P