ADDITIONAL ANTITUMOR ECTEINASCIDINS FROM A CARIBBEAN TUNICATE - CRYSTAL-STRUCTURES AND ACTIVITIES INVIVO
ADDITIONAL ANTITUMOR ECTEINASCIDINS FROM A CARIBBEAN TUNICATE - CRYSTAL-STRUCTURES AND ACTIVITIES INVIVO
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DOI：
10.1073/pnas.89.23.11456
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发表时间：
1992-12-01
影响因子：
11.1
通讯作者：
WANG, AHJ
中科院分区：
文献类型：
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作者：
SAKAI, R;RINEHART, KL;WANG, AHJ
从加勒比海被囊动物甲壳鞘中分离出的鞘皮酸素（Ets）在体内保护小鼠免受P388淋巴瘤、B16黑色素瘤、M5076卵巢肉瘤、Lewis肺癌以及LX-1人肺癌和MX-1人乳腺癌异种移植瘤的侵袭。用Et 729的21- o -甲基-N-12-甲酰基衍生物和Et 743的天然N-12-氧化物单晶研究了两种三（四氢异喹啉）Et的晶体结构。从同一生物中分离出的另一类Et， Et 722和Et 736，通过核磁共振和快速原子轰击质谱鉴定为四氢- β -羰基取代双（四氢异喹啉）结构。
Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N-12-formyl derivative of Et 729 and the natural N-12 -oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-beta-carboline-substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.