Nicotine Exposure by Device Type among Adult Electronic Nicotine Delivery System Users in the Population Assessment of Tobacco and Health Study, 2015-2016.
Nicotine Exposure by Device Type among Adult Electronic Nicotine Delivery System Users in the Population Assessment of Tobacco and Health Study, 2015-2016.
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DOI：
10.1158/1055-9965.epi-20-0317
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Chang CM
中科院分区：
文献类型：
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作者：
Rostron BL;Coleman B;Cheng YC;Kimmel HL;Oniyide O;Wang L;Chang CM
以前的研究已经检查了开放式和封闭式电子尼古丁传递系统（ENDS）使用者的特征，但这些使用者中尼古丁暴露的人口水平信息尚未获得。我们分析了2015年10月至2016年10月收集的烟草与健康人口评估（PATH）研究第三波的尼古丁生物标志物和调查数据。我们确定了277名纯电子烟使用者和468名双烟和电子烟使用者，并根据设备类型和其他特征（如使用频率和电子烟液体风味）分析了尿液样本中尼古丁及其代谢物的浓度。在排他性ENDS使用者中，开放系统使用者的总尼古丁暴露（TNE-2）水平高于封闭系统使用者（肌酐8.8 μmol/g （95% CI=5.3, 14.8 μmol/g）和2.0 μmol/g (95% CI=0.7, 5.4 μmol/g)）。然而，当开放和封闭系统用户被分层为每日终端用户(26.4 μmol/g （95% CI=20.1, 34.7 μmol/g) vs. 27.1 μmol/g (95% CI=16.4, 44.9 μmol/g)）和非每日终端用户(0.5 μmol/g （95% CI=0.1, 1.9 μmol/g) vs. 0.2 μmol/g (95% CI=0.0, 0.7 μmol/g)）时，TNE-2浓度相似。双重使用者通常比单一使用者接触到更多的尼古丁。研究发现，与封闭系统使用者相比，完全开放系统ENDS使用者的尼古丁暴露量更高，但按使用频率对使用者进行分层时，尼古丁暴露水平相似。这些结果表明，具有相似使用模式的专用ENDS使用者，无论他们使用的是开放式还是封闭式系统设备，都能获得相当水平的尼古丁。
Previous studies have examined the characteristics of open and closed system electronic nicotine delivery system (ENDS) users, but population-level information on nicotine exposure among these users has not been available. We analyzed nicotine biomarker and survey data from Wave 3 of the Population Assessment of Tobacco and Health (PATH) Study collected from October 2015 to October 2016. We identified 277 exclusive ENDS users and 468 dual cigarette and ENDS users and analyzed concentrations of nicotine and its metabolites obtained from urine samples by device type and other characteristics such as frequency of use and e-liquid flavor. Among exclusive ENDS users, open system users had higher levels of total nicotine exposure (TNE-2) than closed system users (8.8 μmol/g creatinine (95% CI=5.3, 14.8 μmol/g) vs. 2.0 μmol/g (95% CI=0.7, 5.4 μmol/g). However, TNE-2 concentrations were similar when open and closed system users were stratified as daily (26.4 μmol/g (95% CI=20.1, 34.7 μmol/g) vs. 27.1 μmol/g (95% CI=16.4, 44.9 μmol/g)) and non-daily (0.5 μmol/g (95% CI=0.1, 1.9 μmol/g) vs. 0.2 μmol/g (95% CI=0.0, 0.7 μmol/g)) ENDS users. Dual users generally had higher nicotine exposure than exclusive users. Nicotine exposure was observed to be higher among exclusive open system ENDS users compared to closed system users, but levels were similar when users were stratified by frequency of use. These results suggest that exclusive ENDS users with similar use patterns receive comparable levels of nicotine, regardless of whether they use open or closed system devices.