Insights from an information thermodynamics analysis of a synthetic molecular motor
Insights from an information thermodynamics analysis of a synthetic molecular motor
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DOI：
10.1038/s41557-022-00899-z
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发表时间：
2022-03-17
期刊：
影响因子：
21.8
通讯作者：
Roberts, Benjamin M. W.
中科院分区：
文献类型：
--
作者：
Amano, Shuntaro;Esposito, Massimiliano;Roberts, Benjamin M. W.
信息是物理的，这一认识已经改变了测量和通信的物理学。然而，化学系统中信息、能量和力学之间的流动在很大程度上仍未被探索。在这里，我们从信息热力学的角度分析了一个极简自主化学驱动的分子马达，这是一个定量地将信息与其他热力学参数联系起来的框架。该处理揭示了定向运动是如何通过“能量流”和“信息流”从化学到机械（构象和/或共构象）过程的自由能转移产生的。它提供了对分子马达的一般热力学水平的理解，补充了先前基于动力学的分析，并对机器设计具有实际意义。根据动力学分析，我们发现动力冲程不影响化学驱动机器的方向性。然而，我们发现功率冲程可以调节电机速度、自由能传递效率和每循环消耗的燃料分子数。这可能有助于解释这种（共）构象变化在生物机器中的作用，并说明化学系统中能量和信息之间的相互作用。
Information is physical, a realization that has transformed the physics of measurement and communication. However, the flow between information, energy and mechanics in chemical systems remains largely unexplored. Here we analyse a minimalist autonomous chemically driven molecular motor in terms of information thermodynamics, a framework that quantitatively relates information to other thermodynamic parameters. The treatment reveals how directional motion is generated by free energy transfer from chemical to mechanical (conformational and/or co-conformational) processes by 'energy flow' and 'information flow'. It provides a thermodynamic level of understanding of molecular motors that is general, complements previous analyses based on kinetics and has practical implications for machine design. In line with kinetic analysis, we find that power strokes do not affect the directionality of chemically driven machines. However, we find that power strokes can modulate motor velocity, the efficiency of free energy transfer and the number of fuel molecules consumed per cycle. This may help explain the role of such (co-)conformational changes in biomachines and illustrates the interplay between energy and information in chemical systems.