GOx@ZIF-8(NiPd) Nanoflower: An Artificial Enzyme System for Tandem Catalysis
GOx@ZIF-8(NiPd) Nanoflower: An Artificial Enzyme System for Tandem Catalysis
复制标题
GOx@ZIF-8(NiPd) Nanoflower：串联催化的人工酶系统
DOI：
10.1002/anie.201710418
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发表时间：
2017-12-11
影响因子：
16.6
通讯作者：
Dong, Shaojun
中科院分区：
文献类型：
--
作者：
Wang, Qingqing;Zhang, Xueping;Dong, Shaojun
我们报道了一种制备串联催化人工酶体系的简便方法。采用共沉淀法将NiPd中空纳米颗粒和葡萄糖氧化酶（GOx）同时固定在沸石咪唑酸骨架8 （ZIF-8）上。制备的GOx@ZIF-8（NiPd）纳米花不仅表现出NiPd中空纳米粒子的过氧化物酶样活性，而且保持了GOx的酶活性。通过GOx@ZIF-8（NiPd）多酶体系实现了葡萄糖快速检测比色传感器。此外，GOx@ZIF-8（NiPd）修饰电极对GOx具有良好的生物活性，对氧还原反应（ORR）具有较高的电催化活性，也可用于葡萄糖的电化学检测。
We report a facile approach to prepare an artificial enzyme system for tandem catalysis. NiPd hollow nanoparticles and glucose oxidase (GOx) were simultaneously immobilized on the zeolitic imidazolate framework8 (ZIF-8) via a co-precipitation method. The as-prepared GOx@ZIF-8(NiPd) nanoflower not only exhibited the peroxidase-like activity of NiPd hollow nanoparticles but also maintained the enzymatic activity of GOx. A colorimetric sensor for rapid detection of glucose was realized through the GOx@ZIF-8(NiPd) based multi-enzyme system. Moreover, the GOx@ZIF-8(NiPd) modified electrode showed good bioactivity of GOx and high electrocatalytic activity for the oxygen reduction reaction (ORR), which could also be used for electrochemical detection of glucose.