Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort - The multiethnic study of atherosclerosis
Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort - The multiethnic study of atherosclerosis
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DOI：
10.1001/archopht.125.4.534
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发表时间：
2007-04-01
影响因子：
--
通讯作者：
Sharrett, A. Richey
中科院分区：
文献类型：
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作者：
Klein, Ronald;Klein, Barbara E. K.;Sharrett, A. Richey
目的：在动脉粥样硬化多种族研究中探讨亚临床动脉粥样硬化性心血管疾病（CVD）及其危险因素与年龄相关性黄斑变性（AMD）的关系。方法：本研究包括来自美国 6 个社区的 6176 名年龄 44 至 84 岁的白人、黑人、西班牙裔和华人参与者。亚临床 CVD 的测量是根据标准化方案进行的。使用威斯康星州年龄相关黄斑病变分级系统对眼底图像进行分级。结果：在控制年龄、性别、种族/族裔和研究地点的分析中，早期 AMD 与较高的血清高密度脂蛋白胆固醇水平（每 15 mg/dL 的比值比，1.16；95% 置信区间，1.01-1.36）和存在回声透明颈动脉斑块（目前的比值比）相关。与无斑块相比，0.37；95% 置信区间，0.18-0.74）。研究发现，种族/族裔与早期 AMD 之间存在颈动脉内膜中层厚度、最大颈动脉狭窄严重程度增加、血清甘油三酯水平、亚临床 CVD 严重程度和 Agatston 钙评分之间的相互作用。结论：亚临床 CVD 和 CVD 危险因素与早期 AMD 之间几乎没有关联。早期 AMD 与亚临床动脉粥样硬化性 CVD 某些体征之间的关联研究结果在 4 个种族/族裔群体中有所不同，这表明在从一个种族/族裔群体推广到另一个种族/族裔群体时必须小心谨慎。
Objective: To investigate the relationship of subclinical atherosclerotic cardiovascular disease (CVD) and its risk factors with age-related macular degeneration (AMD) in the Multiethnic Study of Atherosclerosis.Methods: This study included 6176 white, black, Hispanic, and Chinese participants aged 44 to 84 years from 6 communities in the United States. Measurements of subclinical CVD were performed according to standardized protocols. Fundus images were graded using the Wisconsin Age-Related Maculopathy Grading System.Results: In analyses controlled for age, sex, race/ethnicity, and study location, early AMD was associated with a higher serum high-density lipoprotein cholesterol level (odds ratio per 15 mg/dL, 1.16; 95% confidence interval, 1.01-1.36) and the presence of echolucent carotid artery plaque (odds ratio for present vs no plaque, 0.37; 95% confidence interval, 0.18-0.74) in the whole cohort. Interactions of race/ethnicity and early AMD were found for carotid intima-media thickness, increasing severity of maximum carotid artery stenosis, serum triglyceride level, subclinical CVD severity, and Agatston calcium score.Conclusion: Few associations were found between subclinical CVD and CVD risk factors with early AMD. The findings of associations of early AMD with some signs of subclinical atherosclerotic CVD are different among the 4 racial/ethnic groups, which suggests that care must be taken in generalizing from one racial/ethnic group to another.