Inhibitory control of sharp-wave ripple duration during learning in hippocampal recurrent networks.
Inhibitory control of sharp-wave ripple duration during learning in hippocampal recurrent networks.
复制标题
海马循环网络学习过程中尖波纹波持续时间的抑制控制。
DOI：
10.1038/s41593-023-01306-7
复制
发表时间：
2023
影响因子：
25
通讯作者：
Losonczy,Attila
中科院分区：
文献类型：
--
作者：
Vancura,Bert;Geiller,Tristan;Grosmark,Andres;Zhao,Vivian;Losonczy,Attila
海马CA 3区和CA 2区的反复兴奋性连接被认为在产生与学习和记忆巩固密切相关的电生理振荡-尖波波纹（SWRs）中起关键作用。然而，目前尚不清楚定义的抑制性中间神经元群体如何在行为过程中调节这些事件。在这里，我们使用大规模，三维钙成像和回顾性分子识别在小鼠海马体的特征分子鉴定CA 3和CA 2 interneuron活动在SWR相关的记忆巩固和空间导航。我们描述了亚型和区域的具体反应，在行为不同的大脑状态，并发现，SWR之前降低胆囊收缩素表达的中间神经元的活动，其次是增加小白蛋白表达篮细胞的活动。这些动态的大小与驻波比持续时间和行为在依赖于营地的学习。总之，这些结果分配亚型和区域特定的作用，在协调操作和学习相关的可塑性在海马回路的抑制电路。
Recurrent excitatory connections in hippocampal regions CA3 and CA2 are thought to play a key role in the generation of sharp-wave ripples (SWRs), electrophysiological oscillations tightly linked with learning and memory consolidation. However, it remains unknown how defined populations of inhibitory interneurons regulate these events during behavior. Here, we use large-scale, three-dimensional calcium imaging and retrospective molecular identification in the mouse hippocampus to characterize molecularly identified CA3 and CA2 interneuron activity during SWR-associated memory consolidation and spatial navigation. We describe subtype- and region-specific responses during behaviorally distinct brain states and find that SWRs are preceded by decreased cholecystokinin-expressing interneuron activity and followed by increased parvalbumin-expressing basket cell activity. The magnitude of these dynamics correlates with both SWR duration and behavior during hippocampal-dependent learning. Together these results assign subtype- and region-specific roles for inhibitory circuits in coordinating operations and learning-related plasticity in hippocampal recurrent circuits.