New roles for TIM family members in immune regulation
New roles for TIM family members in immune regulation
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DOI：
10.1038/nri2366
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发表时间：
2008-08-01
影响因子：
100.3
通讯作者：
Anderson, Ana C.
中科院分区：
文献类型：
--
作者：
Kuchroo, Vijay K.;Dardalhon, Valerie;Anderson, Ana C.
T细胞免疫球蛋白结构域和黏蛋白结构域（TIM）蛋白家族成员正逐渐成为免疫应答的重要调节因子。顾名思义，TIM蛋白最初被认为是特异性存在于T细胞的分子，主要用于调节辅助性T细胞的应答。然而，最近发现抗原呈递细胞也表达TIM分子，并且新的TIM蛋白配体被鉴定出来，这拓展了TIM蛋白在免疫调节中已知的作用。
Members of the TIM (T-cell immunoglobulin domain and mucin domain) protein family are emerging as important regulators of immune responses. As their names imply, the TIM proteins were originally thought to be T-cell-specific molecules that served mainly to regulate T-helper-cell responses. However, the recent discovery that antigen-presenting cells also express TIM molecules and the identification of new TIM-protein ligands has expanded the known roles of the TIM proteins in immune regulation.