A newly identified Crimean-Congo hemorrhagic fever virus strain in Turkey
A newly identified Crimean-Congo hemorrhagic fever virus strain in Turkey
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DOI：
10.1016/j.ijid.2009.07.017
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发表时间：
2010-09-01
影响因子：
8.4
通讯作者：
Duru, Nilgun Selcuk
中科院分区：
文献类型：
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作者：
Elevli, Murat;Ozkul, Ayse Ayaz;Duru, Nilgun Selcuk
克里米亚-刚果出血热(CCHF)是一种致命的病毒性疾病，在大约30个国家发生。在影响人类健康的扁虱传播病毒中，它的地理范围最广。最近，一名6岁男孩出现发烧、疲劳和食欲不振的主诉。他在演讲前三天透露了伊斯坦布尔农村地区被扁虱叮咬的病史。在扁虱叮咬处检测到充血。实验室检查显示丙氨酸氨基转移酶、天冬氨酸氨基转移酶、乳酸脱氢酶和肌酸磷酸酶水平升高，凝血酶原时间和活化部分凝血活酶时间延长。抗CCHF病毒IgM酶联免疫吸附试验和CCHF RNA逆转录聚合酶链式反应检测均为阳性。系统发育分析表明，该病毒为新的AP92类CCHF毒株，命名为KMAG-HU-07-01(登录号为EU057975)。这位患者可提供有关CCHF感染传播动力学的重要信息。(C)2009年国际传染病学会。爱思唯尔有限公司出版。保留所有权利。
Crimean-Congo hemorrhagic fever (CCHF) is a fatal viral disease that occurs in approximately 30 countries. It has the most extensive geographic range among the tick-borne viruses that affect human health. Recently, a 6-year-old boy presented with complaints of fever, fatigue, and loss of appetite. He revealed a history of tick bite in rural Istanbul three days prior to presentation. A hyperemia was detected at the site of the tick bite. Laboratory tests showed that alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase levels were elevated and that the prothrombin time and activated partial thromboplastin time were prolonged. Anti-CCHF virus IgM ELISA and a reverse transcriptase-PCR assay for CCHF RNA were both positive. Phylogenetic studies revealed that the virus was a new AP92-like CCHF strain, which was named KMAG-Hu-07-01 (accession number EU057975). This patient could provide important information on the transmission dynamics of CCHF infection. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.