Quinolones: from antibiotics to autoinducers.
Quinolones: from antibiotics to autoinducers.
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DOI：
10.1111/j.1574-6976.2010.00247.x
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发表时间：
2011-03
影响因子：
11.3
通讯作者：
Cámara M
中科院分区：
文献类型：
--
作者：
Heeb S;Fletcher MP;Chhabra SR;Diggle SP;Williams P;Cámara M
自从奎宁首次被分离出来以来，已经发现了产生各种喹诺酮化合物的动物、植物和微生物，其中一些具有从抗过敏和抗癌到抗微生物活性的医学上有趣的性质。多年来，这些已经用于许多合成药物的开发，包括成功的氟喹诺酮类抗生素。铜绿假单胞菌和相关细菌产生许多2-烷基-4（1H）-喹诺酮，其中一些表现出抗微生物活性。然而，喹诺酮类如假单胞菌喹诺酮信号和2-庚基-4-羟基喹啉作为群体感应信号分子，控制许多毒力基因的表达作为细胞群体密度的函数。在这里，我们选择性地回顾了这个广泛的双环化合物家族，从天然和合成的抗菌剂到信号分子，特别强调铜绿假单胞菌的生物学。特别是，我们回顾了它们的命名和生物化学，它们作为膜相互作用的化合物，细胞色素bc 1复合物和铁螯合剂的抑制剂的多重属性，以及它们的生物合成和它们的整合到复杂的群体感应调控网络管理的毒力和次级代谢产物基因表达的调节。
Since quinine was first isolated, animals, plants and microorganisms producing a wide variety of quinolone compounds have been discovered, several of which possess medicinally interesting properties ranging from antiallergenic and anticancer to antimicrobial activities. Over the years, these have served in the development of many synthetic drugs, including the successful fluoroquinolone antibiotics. Pseudomonas aeruginosa and related bacteria produce a number of 2-alkyl-4(1H)-quinolones, some of which exhibit antimicrobial activity. However, quinolones such as the Pseudomonas quinolone signal and 2-heptyl-4-hydroxyquinoline act as quorum-sensing signal molecules, controlling the expression of many virulence genes as a function of cell population density. Here, we review selectively this extensive family of bicyclic compounds, from natural and synthetic antimicrobials to signalling molecules, with a special emphasis on the biology of P. aeruginosa. In particular, we review their nomenclature and biochemistry, their multiple properties as membrane-interacting compounds, inhibitors of the cytochrome bc1 complex and iron chelators, as well as the regulation of their biosynthesis and their integration into the intricate quorum-sensing regulatory networks governing virulence and secondary metabolite gene expression.
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影响因子：
4.9
作者：
Cavaco, L. M.;Hasman, H.;Aarestrup, F. M.
通讯作者：
Aarestrup, F. M.
影响因子：
3.6
作者：
Allesen-Holm, M;Barken, KB;Tolker-Nielsen, T
通讯作者：
Tolker-Nielsen, T
影响因子：
3.1
作者：
Calfee, MW;Shelton, JG;Pesci, EC
通讯作者：
Pesci, EC
影响因子：
5
作者：
Attila, Can;Ueda, Akihiro;Wood, Thomas K.
通讯作者：
Wood, Thomas K.
影响因子：
3.2
作者：
Coleman, James P.;Hudson, L. Lynn;Pesci, Everett C.
通讯作者：
Pesci, Everett C.