Muscle fiber and satellite cell apoptosis in the aging human thyroarytenoid muscle: A stereological study with confocal laser scanning microscopy
Muscle fiber and satellite cell apoptosis in the aging human thyroarytenoid muscle: A stereological study with confocal laser scanning microscopy
复制标题
DOI：
10.1067/mhn.2001.116449
复制
发表时间：
2001-07-01
影响因子：
3.4
通讯作者：
Bookman, LM
中科院分区：
文献类型：
--
作者：
Malmgren, LT;Jones, CE;Bookman, LM
目的：本研究确定了凋亡的肌核和卫星细胞的数量密度的变化在年龄相关的甲杓肌重塑中的作用（CTA）.设计：凋亡的肌核和卫星细胞的数量密度的变化估计整个TA通过使用体视学技术。研究结果：1型肌纤维的N-v（凋亡肌核）（纤维类型）和凋亡肌核百分比（P <0.05）增加，而2型肌纤维无此变化。N-v凋亡卫星细胞、N-纤维型凋亡细胞、N-v凋亡细胞。（P < 0.05）及凋亡卫星细胞百分率结论TA中细胞凋亡可能参与了年龄相关性纤维丢失和萎缩。基于降低细胞凋亡频率的治疗技术可以阻断TA中与年龄相关的纤维丢失和萎缩。
OBJECTIVE: This study determines the role of changes in numerical densities of apoptotic myonuclei and satellite cells in age-related remodeling of the thyroarytenoid muscle CTA).DESIGN: Changes in numerical densities of apoptotic myonuclei and satellite cells were estimated for the entire TA by using stereological techniques. RESULTS: There was an increase in N-v (apoptotic myonucreus,) (fiber type) (P < 0.05) and in the percentage of apoptotic myonuclei (P < 0.05) in type 1 but not in type 2 muscle fibers. There was also an increase in N-v apoptotic satellite cell,N- fiber type (P < 0.05) and in the percentage of apoptotic satellite cells (P < 0.05) in type 1 fibers but not in type 2 fibers.CONCLUSION Apoptosis may contribute to age-related fiber loss and atrophy in the TA.SIGNIFICANCE: Therapeutic techniques based on decreasing the frequency of apoptosis may block age-related fiber loss and atrophy in the TA.