Oral tongue squamous cell carcinoma: recurrent disease is associated with histopathologic risk score and young age
Oral tongue squamous cell carcinoma: recurrent disease is associated with histopathologic risk score and young age
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DOI：
10.1007/s00432-009-0749-3
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发表时间：
2010-07-01
影响因子：
3.6
通讯作者：
Taicher, Shlomo
中科院分区：
文献类型：
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作者：
Vered, Marilena;Dayan, Dan;Taicher, Shlomo
应用 Brandwein-Gensler 等人的组织病理学风险评分 (RS) 系统，并评估其对一系列口腔舌癌病例中局部区域复发和总体生存的影响，以及患者年龄和边缘状态的变量。切除标本的切片 (N = 50) 被提交给三个组成部分的 RS 分配：最坏的浸润模式、淋巴细胞浸润和神经周围浸润。就复发和生存而言，0-2 的风险评分被归类为低到中，RSs 千分之一3 被归类为高。如果肿瘤距离其千分之一5毫米，则边缘被认为是“干净的”，否则它们被定义为“阳性”。千分之几的患者 60 岁被认为是“年轻”的，而 60 岁以上的患者被认为是“老年”。采用单变量 Kaplan-Meier 生存分析和逐步向前选择检验的 Cox 多变量回归模型。单变量分析显示，局部区域复发受到高 RS（P = 0.011）、“年轻”年龄（P = 0.027）和阳性切缘（P = 0.027）的负面影响。多变量分析显示，高RS（风险比11.14；P = 0.022）和“年轻”年龄（风险比3.41；P = 0.022）会增加复发风险。与低中低评分的“年轻”患者（P = 0.008）和中低评分和高 RS 的“老年”患者（分别为 P = 0.012 和 P = 0.011）相比，高 RS 的“年轻”患者的复发率更高。组织病理学 RS 可用于识别年龄 < 60 岁的口腔舌癌复发率高的患者亚组，无论其复发率如何保证金状态。
To apply the Brandwein-Gensler et al.'s histopathologic risk score (RS) system and to evaluate its impact on locoregional recurrence and overall survival in a series of cases of oral tongue cancer, along with variables of patient age and margin status.Sections of the resection specimens (N = 50) were submitted to a RS assignment of three components: the worst pattern of invasion, lymphocytic infiltration and perineural invasion. Risk scores of 0-2 were classified as low-to-intermediate and RSs a parts per thousand yen3 were classified as high with respect to recurrence and survival. Margins were considered as "clean" if the tumor was a parts per thousand yen5 mm away from them, otherwise they were defined as "positive". Patients a parts per thousand currency sign60 years were considered "young" and those > 60 years "old". Kaplan-Meier survival analysis with univariate and Cox multivariate regression model with stepwise forward selection tests were used.Univariate analysis showed that locoregional recurrence was negatively influenced by high RSs (P = 0.011), "young" age (P = 0.027) and positive margins (P = 0.027). Multivariate analysis revealed that the risk of recurrence was increased by high RSs (hazard ratio 11.14; P = 0.022) and "young" age (hazard ratio 3.41; P = 0.022). "Young" patients with high RSs had a higher frequency of recurrence rate compared to "young" patients with low-to-intermediate scores (P = 0.008) and "old" patients with low-to-intermediate and high RSs (P = 0.012 and P = 0.011, respectively).The histopathologic RS can serve to identify a subgroup of patients < 60 years who have a high recurrence rate of oral tongue cancer, irrespective of the margin status.